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PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle.
Fang L, Yan Y, Komuves LG, Yonkovich S, Sullivan CM, Stringer B, Galbraith S, Lokker NA, Hwang SS, Nurden P, Phillips DR, Giese NA. Fang L, et al. Among authors: giese na. Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):787-92. doi: 10.1161/01.atv.0000120785.82268.8b. Arterioscler Thromb Vasc Biol. 2004. PMID: 15061151
CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML).
Kelly LM, Yu JC, Boulton CL, Apatira M, Li J, Sullivan CM, Williams I, Amaral SM, Curley DP, Duclos N, Neuberg D, Scarborough RM, Pandey A, Hollenbach S, Abe K, Lokker NA, Gilliland DG, Giese NA. Kelly LM, et al. Among authors: giese na. Cancer Cell. 2002 Jun;1(5):421-32. doi: 10.1016/s1535-6108(02)00070-3. Cancer Cell. 2002. PMID: 12124172 Free article.
Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor.
Heath JA, Mehrotra MM, Chi S, Yu JC, Hutchaleelaha A, Hollenbach SJ, Giese NA, Scarborough RM, Pandey A. Heath JA, et al. Among authors: giese na. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4867-72. doi: 10.1016/j.bmcl.2004.07.041. Bioorg Med Chem Lett. 2004. PMID: 15341941
PDGF-D, a new protease-activated growth factor.
LaRochelle WJ, Jeffers M, McDonald WF, Chillakuru RA, Giese NA, Lokker NA, Sullivan C, Boldog FL, Yang M, Vernet C, Burgess CE, Fernandes E, Deegler LL, Rittman B, Shimkets J, Shimkets RA, Rothberg JM, Lichenstein HS. LaRochelle WJ, et al. Among authors: giese na. Nat Cell Biol. 2001 May;3(5):517-21. doi: 10.1038/35074593. Nat Cell Biol. 2001. PMID: 11331882
Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives.
Matsuno K, Ichimura M, Nakajima T, Tahara K, Fujiwara S, Kase H, Ushiki J, Giese NA, Pandey A, Scarborough RM, Lokker NA, Yu JC, Irie J, Tsukuda E, Ide S, Oda S, Nomoto Y. Matsuno K, et al. Among authors: giese na. J Med Chem. 2002 Jul 4;45(14):3057-66. doi: 10.1021/jm010428o. J Med Chem. 2002. PMID: 12086491
156 results