Hui HC - Search Results

1

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.

Mackman RL, Hui HC, Breitenbucher JG, Katz BA, Luong C, Martelli A, McGee D, Radika K, Sendzik M, Spencer JR, Sprengeler PA, Tario J, Verner E, Wang J. Mackman RL, et al. Among authors: hui hc. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2019-22. doi: 10.1016/s0960-894x(02)00311-6. Bioorg Med Chem Lett. 2002. PMID: 12113832

2

Isozyme-specific glutathione-S-transferase inhibitors: design and synthesis.

Lyttle MH, Hocker MD, Hui HC, Caldwell CG, Aaron DT, Engqvist-Goldstein A, Flatgaard JE, Bauer KE. Lyttle MH, et al. Among authors: hui hc. J Med Chem. 1994 Jan 7;37(1):189-94. doi: 10.1021/jm00027a024. J Med Chem. 1994. PMID: 8289195

3

Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.

Verner E, Katz BA, Spencer JR, Allen D, Hataye J, Hruzewicz W, Hui HC, Kolesnikov A, Li Y, Luong C, Martelli A, Radika K, Rai R, She M, Shrader W, Sprengeler PA, Trapp S, Wang J, Young WB, Mackman RL. Verner E, et al. Among authors: hui hc. J Med Chem. 2001 Aug 16;44(17):2753-71. doi: 10.1021/jm0100638. J Med Chem. 2001. PMID: 11495587

4

Exploiting subsite S1 of trypsin-like serine proteases for selectivity: potent and selective inhibitors of urokinase-type plasminogen activator.

Mackman RL, Katz BA, Breitenbucher JG, Hui HC, Verner E, Luong C, Liu L, Sprengeler PA. Mackman RL, et al. Among authors: hui hc. J Med Chem. 2001 Nov 8;44(23):3856-71. doi: 10.1021/jm010244+. J Med Chem. 2001. PMID: 11689072

5

Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.

Katz BA, Sprengeler PA, Luong C, Verner E, Elrod K, Kirtley M, Janc J, Spencer JR, Breitenbucher JG, Hui H, McGee D, Allen D, Martelli A, Mackman RL. Katz BA, et al. Chem Biol. 2001 Nov;8(11):1107-21. doi: 10.1016/s1074-5521(01)00084-9. Chem Biol. 2001. PMID: 11731301

6

Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.

Katz BA, Elrod K, Verner E, Mackman RL, Luong C, Shrader WD, Sendzik M, Spencer JR, Sprengeler PA, Kolesnikov A, Tai VW, Hui HC, Breitenbucher JG, Allen D, Janc JW. Katz BA, et al. Among authors: hui hc. J Mol Biol. 2003 May 23;329(1):93-120. doi: 10.1016/s0022-2836(03)00399-1. J Mol Biol. 2003. PMID: 12742021

7

Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.

Mackman RL, Zhang L, Prasad V, Boojamra CG, Douglas J, Grant D, Hui H, Kim CU, Laflamme G, Parrish J, Stoycheva AD, Swaminathan S, Wang K, Cihlar T. Mackman RL, et al. Bioorg Med Chem. 2007 Aug 15;15(16):5519-28. doi: 10.1016/j.bmc.2007.05.047. Epub 2007 May 25. Bioorg Med Chem. 2007. PMID: 17562366

8

Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates.

Mackman RL, Boojamra CG, Prasad V, Zhang L, Lin KY, Petrakovsky O, Babusis D, Chen J, Douglas J, Grant D, Hui HC, Kim CU, Markevitch DY, Vela J, Ray A, Cihlar T. Mackman RL, et al. Among authors: hui hc. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6785-9. doi: 10.1016/j.bmcl.2007.10.038. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 18029175

9

Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.

Ray AS, Vela JE, Boojamra CG, Zhang L, Hui H, Callebaut C, Stray K, Lin KY, Gao Y, Mackman RL, Cihlar T. Ray AS, et al. Antimicrob Agents Chemother. 2008 Feb;52(2):648-54. doi: 10.1128/AAC.01209-07. Epub 2007 Dec 3. Antimicrob Agents Chemother. 2008. PMID: 18056281 Free PMC article.

10

Synthesis and anti-HIV activity of 2'-fluorine modified nucleoside phosphonates: analogs of GS-9148.

Mackman RL, Lin KY, Boojamra CG, Hui H, Douglas J, Grant D, Petrakovsky O, Prasad V, Ray AS, Cihlar T. Mackman RL, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1116-9. doi: 10.1016/j.bmcl.2007.11.126. Epub 2007 Dec 5. Bioorg Med Chem Lett. 2008. PMID: 18082402

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