Kew JN - Search Results

1

Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity.

Ballard TM, Pauly-Evers M, Higgins GA, Ouagazzal AM, Mutel V, Borroni E, Kemp JA, Bluethmann H, Kew JN. Ballard TM, et al. Among authors: kew jn. J Neurosci. 2002 Aug 1;22(15):6713-23. doi: 10.1523/JNEUROSCI.22-15-06713.2002. J Neurosci. 2002. PMID: 12151550 Free PMC article.

2

PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.

Richards JG, Higgins GA, Ouagazzal AM, Ozmen L, Kew JN, Bohrmann B, Malherbe P, Brockhaus M, Loetscher H, Czech C, Huber G, Bluethmann H, Jacobsen H, Kemp JA. Richards JG, et al. Among authors: kew jn. J Neurosci. 2003 Oct 1;23(26):8989-9003. doi: 10.1523/JNEUROSCI.23-26-08989.2003. J Neurosci. 2003. PMID: 14523101 Free PMC article.

3

Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons.

Kew JN, Richards JG, Mutel V, Kemp JA. Kew JN, et al. J Neurosci. 1998 Mar 15;18(6):1935-43. doi: 10.1523/JNEUROSCI.18-06-01935.1998. J Neurosci. 1998. PMID: 9482779 Free PMC article. Review.

4

An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones.

Kew JN, Kemp JA. Kew JN, et al. J Physiol. 1998 Oct 1;512 ( Pt 1)(Pt 1):17-28. doi: 10.1111/j.1469-7793.1998.017bf.x. J Physiol. 1998. PMID: 9729614 Free PMC article.

5

Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site.

Kew JN, Koester A, Moreau JL, Jenck F, Ouagazzal AM, Mutel V, Richards JG, Trube G, Fischer G, Montkowski A, Hundt W, Reinscheid RK, Pauly-Evers M, Kemp JA, Bluethmann H. Kew JN, et al. J Neurosci. 2000 Jun 1;20(11):4037-49. doi: 10.1523/JNEUROSCI.20-11-04037.2000. J Neurosci. 2000. PMID: 10818139 Free PMC article.

6

Differential regulation of synaptic transmission by mGlu2 and mGlu3 at the perforant path inputs to the dentate gyrus and CA1 revealed in mGlu2 -/- mice.

Kew JN, Pflimlin MC, Kemp JA, Mutel V. Kew JN, et al. Neuropharmacology. 2002 Aug;43(2):215-21. doi: 10.1016/s0028-3908(02)00084-9. Neuropharmacology. 2002. PMID: 12213275

7

Identification and characterization of a novel splice variant of the metabotropic glutamate receptor 5 gene in human hippocampus and cerebellum.

Malherbe P, Kew JN, Richards JG, Knoflach F, Kratzeisen C, Zenner MT, Faull RL, Kemp JA, Mutel V. Malherbe P, et al. Among authors: kew jn. Brain Res Mol Brain Res. 2002 Dec 30;109(1-2):168-78. doi: 10.1016/s0169-328x(02)00557-0. Brain Res Mol Brain Res. 2002. PMID: 12531526

8

Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket.

Malherbe P, Mutel V, Broger C, Perin-Dureau F, Kemp JA, Neyton J, Paoletti P, Kew JN. Malherbe P, et al. Among authors: kew jn. J Pharmacol Exp Ther. 2003 Dec;307(3):897-905. doi: 10.1124/jpet.103.056291. Epub 2003 Oct 8. J Pharmacol Exp Ther. 2003. PMID: 14534359

9

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent.

Higgins GA, Ballard TM, Kew JN, Richards JG, Kemp JA, Adam G, Woltering T, Nakanishi S, Mutel V. Higgins GA, et al. Among authors: kew jn. Neuropharmacology. 2004 Jun;46(7):907-17. doi: 10.1016/j.neuropharm.2004.01.018. Neuropharmacology. 2004. PMID: 15081787

10

A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory.

Higgins GA, Kew JN, Richards JG, Takeshima H, Jenck F, Adam G, Wichmann J, Kemp JA, Grottick AJ. Higgins GA, et al. Among authors: kew jn. Eur J Neurosci. 2002 Mar;15(5):911-22. doi: 10.1046/j.1460-9568.2002.01926.x. Eur J Neurosci. 2002. PMID: 11906533

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