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Medulloblastoma growth inhibition by hedgehog pathway blockade.
Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale J, Olson JM, Beachy PA. Berman DM, et al. Among authors: chen jk. Science. 2002 Aug 30;297(5586):1559-61. doi: 10.1126/science.1073733. Science. 2002. PMID: 12202832
Small molecule modulation of Smoothened activity.
Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. Chen JK, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6. doi: 10.1073/pnas.182542899. Epub 2002 Oct 21. Proc Natl Acad Sci U S A. 2002. PMID: 12391318 Free PMC article.
Stromal response to Hedgehog signaling restrains pancreatic cancer progression.
Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, Fitamant J, Jones PD, Ghanta KS, Kawano S, Nagle JM, Deshpande V, Boucher Y, Kato T, Chen JK, Willmann JK, Bardeesy N, Beachy PA. Lee JJ, et al. Among authors: chen jk. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3091-100. doi: 10.1073/pnas.1411679111. Epub 2014 Jul 14. Proc Natl Acad Sci U S A. 2014. PMID: 25024225 Free PMC article.
Control of inflammation by stromal Hedgehog pathway activation restrains colitis.
Lee JJ, Rothenberg ME, Seeley ES, Zimdahl B, Kawano S, Lu WJ, Shin K, Sakata-Kato T, Chen JK, Diehn M, Clarke MF, Beachy PA. Lee JJ, et al. Among authors: chen jk. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7545-E7553. doi: 10.1073/pnas.1616447113. Epub 2016 Nov 4. Proc Natl Acad Sci U S A. 2016. PMID: 27815529 Free PMC article.
A crucial requirement for Hedgehog signaling in small cell lung cancer.
Park KS, Martelotto LG, Peifer M, Sos ML, Karnezis AN, Mahjoub MR, Bernard K, Conklin JF, Szczepny A, Yuan J, Guo R, Ospina B, Falzon J, Bennett S, Brown TJ, Markovic A, Devereux WL, Ocasio CA, Chen JK, Stearns T, Thomas RK, Dorsch M, Buonamici S, Watkins DN, Peacock CD, Sage J. Park KS, et al. Among authors: chen jk. Nat Med. 2011 Oct 9;17(11):1504-8. doi: 10.1038/nm.2473. Nat Med. 2011. PMID: 21983857 Free PMC article.
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK. Hyman JM, et al. Among authors: chen jk. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7. doi: 10.1073/pnas.0907134106. Epub 2009 Aug 5. Proc Natl Acad Sci U S A. 2009. PMID: 19666565 Free PMC article.
1,022 results