Okar DA - Search Results

1

Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice using in vivo (13)C NMR measurements of hepatic carbohydrate metabolism.

Choi IY, Wu C, Okar DA, Lange AJ, Gruetter R. Choi IY, et al. Among authors: okar da. Eur J Biochem. 2002 Sep;269(18):4418-26. Eur J Biochem. 2002. PMID: 12230553 Free article.

2

Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes.

Wu C, Okar DA, Newgard CB, Lange AJ. Wu C, et al. Among authors: okar da. Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E38-45. doi: 10.1152/ajpendo.2002.282.1.E38. Am J Physiol Endocrinol Metab. 2002. PMID: 11739081 Free article.

3

A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.

Wu C, Okar DA, Stoeckman AK, Peng LJ, Herrera AH, Herrera JE, Towle HC, Lange AJ. Wu C, et al. Among authors: okar da. Endocrinology. 2004 Feb;145(2):650-8. doi: 10.1210/en.2003-1290. Epub 2003 Nov 14. Endocrinology. 2004. PMID: 14617577

4

Reduction of hepatic glucose production as a therapeutic target in the treatment of diabetes.

Wu C, Okar DA, Kang J, Lange AJ. Wu C, et al. Among authors: okar da. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Mar;5(1):51-9. doi: 10.2174/1568008053174769. Curr Drug Targets Immune Endocr Metabol Disord. 2005. PMID: 15777204 Review.

5

The roles of Glu-327 and His-446 in the bisphosphatase reaction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase probed by NMR spectroscopic and mutational analyses of the enzyme in the transient phosphohistidine intermediate complex.

Okar DA, Live DH, Kirby TL, Karschnia EJ, von Weymarn LB, Armitage IM, Lange AJ. Okar DA, et al. Biochemistry. 1999 Apr 6;38(14):4471-9. doi: 10.1021/bi9828728. Biochemistry. 1999. PMID: 10194369

6

Fructose-2,6-bisphosphate and control of carbohydrate metabolism in eukaryotes.

Okar DA, Lange AJ. Okar DA, et al. Biofactors. 1999;10(1):1-14. doi: 10.1002/biof.5520100101. Biofactors. 1999. PMID: 10475585 Review.

7

Mechanism of the bisphosphatase reaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase probed by (1)H-(15)N NMR spectroscopy.

Okar DA, Live DH, Devany MH, Lange AJ. Okar DA, et al. Biochemistry. 2000 Aug 15;39(32):9754-62. doi: 10.1021/bi000815k. Biochemistry. 2000. PMID: 10933792

8

Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production.

Wu C, Okar DA, Newgard CB, Lange AJ. Wu C, et al. Among authors: okar da. J Clin Invest. 2001 Jan;107(1):91-8. doi: 10.1172/JCI11103. J Clin Invest. 2001. PMID: 11134184 Free PMC article.

9

Regulation of the regulatory enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

Okar DA, Wu C, Lange AJ. Okar DA, et al. Adv Enzyme Regul. 2004;44:123-54. doi: 10.1016/j.advenzreg.2003.11.006. Adv Enzyme Regul. 2004. PMID: 15581487 Review. No abstract available.

10

Identification and characterization of the ATP-binding site in human pancreatic glucokinase.

Marotta DE, Anand GR, Anderson TA, Miller SP, Okar DA, Levitt DG, Lange AJ. Marotta DE, et al. Among authors: okar da. Arch Biochem Biophys. 2005 Apr 1;436(1):23-31. doi: 10.1016/j.abb.2005.01.018. Arch Biochem Biophys. 2005. PMID: 15752705

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