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Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.
Matsuno K, Nakajima T, Ichimura M, Giese NA, Yu JC, Lokker NA, Ushiki J, Ide S, Oda S, Nomoto Y. Matsuno K, et al. Among authors: nomoto y. J Med Chem. 2002 Sep 26;45(20):4513-23. doi: 10.1021/jm0201114. J Med Chem. 2002. PMID: 12238930
Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives.
Matsuno K, Ichimura M, Nakajima T, Tahara K, Fujiwara S, Kase H, Ushiki J, Giese NA, Pandey A, Scarborough RM, Lokker NA, Yu JC, Irie J, Tsukuda E, Ide S, Oda S, Nomoto Y. Matsuno K, et al. Among authors: nomoto y. J Med Chem. 2002 Jul 4;45(14):3057-66. doi: 10.1021/jm010428o. J Med Chem. 2002. PMID: 12086491
Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.
Matsuno K, Seishi T, Nakajima T, Ichimura M, Giese NA, Yu JC, Oda S, Nomoto Y. Matsuno K, et al. Among authors: nomoto y. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3001-4. doi: 10.1016/s0960-894x(03)00634-6. Bioorg Med Chem Lett. 2003. PMID: 12941321
Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 3. Replacement of quinazoline moiety and improvement of metabolic polymorphism of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.
Matsuno K, Ushiki J, Seishi T, Ichimura M, Giese NA, Yu JC, Takahashi S, Oda S, Nomoto Y. Matsuno K, et al. Among authors: nomoto y. J Med Chem. 2003 Nov 6;46(23):4910-25. doi: 10.1021/jm020505v. J Med Chem. 2003. PMID: 14584942
477 results