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The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts.
Myers AJ, Pittman AM, Zhao AS, Rohrer K, Kaleem M, Marlowe L, Lees A, Leung D, McKeith IG, Perry RH, Morris CM, Trojanowski JQ, Clark C, Karlawish J, Arnold S, Forman MS, Van Deerlin V, de Silva R, Hardy J. Myers AJ, et al. Among authors: clark c. Neurobiol Dis. 2007 Mar;25(3):561-70. doi: 10.1016/j.nbd.2006.10.018. Epub 2006 Dec 15. Neurobiol Dis. 2007. PMID: 17174556
Clinical and pathological continuum of multisystem TDP-43 proteinopathies.
Geser F, Martinez-Lage M, Robinson J, Uryu K, Neumann M, Brandmeir NJ, Xie SX, Kwong LK, Elman L, McCluskey L, Clark CM, Malunda J, Miller BL, Zimmerman EA, Qian J, Van Deerlin V, Grossman M, Lee VM, Trojanowski JQ. Geser F, et al. Arch Neurol. 2009 Feb;66(2):180-9. doi: 10.1001/archneurol.2008.558. Arch Neurol. 2009. PMID: 19204154 Free PMC article.
5,852 results