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Page 1
In situ assembly of enzyme inhibitors using extended tethering.
Erlanson DA, Lam JW, Wiesmann C, Luong TN, Simmons RL, DeLano WL, Choong IC, Burdett MT, Flanagan WM, Lee D, Gordon EM, O'Brien T. Erlanson DA, et al. Among authors: delano wl. Nat Biotechnol. 2003 Mar;21(3):308-14. doi: 10.1038/nbt786. Epub 2003 Feb 3. Nat Biotechnol. 2003. PMID: 12563278
Identification of potent and novel small-molecule inhibitors of caspase-3.
Allen DA, Pham P, Choong IC, Fahr B, Burdett MT, Lew W, DeLano WL, Gordon EM, Lam JW, O'Brien T, Lee D. Allen DA, et al. Among authors: delano wl. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3651-5. doi: 10.1016/j.bmcl.2003.08.024. Bioorg Med Chem Lett. 2003. PMID: 14552750
Binding of small molecules to an adaptive protein-protein interface.
Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC. Arkin MR, et al. Among authors: delano wl. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1603-8. doi: 10.1073/pnas.252756299. Epub 2003 Feb 11. Proc Natl Acad Sci U S A. 2003. PMID: 12582206 Free PMC article.
Hot-spot mimicry of a cytokine receptor by a small molecule.
Thanos CD, DeLano WL, Wells JA. Thanos CD, et al. Among authors: delano wl. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15422-7. doi: 10.1073/pnas.0607058103. Epub 2006 Oct 10. Proc Natl Acad Sci U S A. 2006. PMID: 17032757 Free PMC article.
Drug discovery at signaling interfaces.
Wells J, Arkin M, Braisted A, DeLano W, McDowell B, Oslob J, Raimundo B, Randal M. Wells J, et al. Ernst Schering Res Found Workshop. 2003;(42):19-27. doi: 10.1007/978-3-662-05314-0_3. Ernst Schering Res Found Workshop. 2003. PMID: 12664533 No abstract available.
14 results