Erlanson DA - Search Results

1

Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design.

Choong IC, Lew W, Lee D, Pham P, Burdett MT, Lam JW, Wiesmann C, Luong TN, Fahr B, DeLano WL, McDowell RS, Allen DA, Erlanson DA, Gordon EM, O'Brien T. Choong IC, et al. Among authors: erlanson da. J Med Chem. 2002 Nov 7;45(23):5005-22. doi: 10.1021/jm020230j. J Med Chem. 2002. PMID: 12408711

2

Site-directed ligand discovery.

Erlanson DA, Braisted AC, Raphael DR, Randal M, Stroud RM, Gordon EM, Wells JA. Erlanson DA, et al. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9367-72. doi: 10.1073/pnas.97.17.9367. Proc Natl Acad Sci U S A. 2000. PMID: 10944209 Free PMC article.

3

In situ assembly of enzyme inhibitors using extended tethering.

Erlanson DA, Lam JW, Wiesmann C, Luong TN, Simmons RL, DeLano WL, Choong IC, Burdett MT, Flanagan WM, Lee D, Gordon EM, O'Brien T. Erlanson DA, et al. Nat Biotechnol. 2003 Mar;21(3):308-14. doi: 10.1038/nbt786. Epub 2003 Feb 3. Nat Biotechnol. 2003. PMID: 12563278

4

Discovery of a new phosphotyrosine mimetic for PTP1B using breakaway tethering.

Erlanson DA, McDowell RS, He MM, Randal M, Simmons RL, Kung J, Waight A, Hansen SK. Erlanson DA, et al. J Am Chem Soc. 2003 May 14;125(19):5602-3. doi: 10.1021/ja034440c. J Am Chem Soc. 2003. PMID: 12733877

5

Tethering: fragment-based drug discovery.

Erlanson DA, Wells JA, Braisted AC. Erlanson DA, et al. Annu Rev Biophys Biomol Struct. 2004;33:199-223. doi: 10.1146/annurev.biophys.33.110502.140409. Annu Rev Biophys Biomol Struct. 2004. PMID: 15139811 Review.

6

Fragment-based drug discovery.

Erlanson DA, McDowell RS, O'Brien T. Erlanson DA, et al. J Med Chem. 2004 Jul 1;47(14):3463-82. doi: 10.1021/jm040031v. J Med Chem. 2004. PMID: 15214773 Review. No abstract available.

7

Allosteric inhibition of protein tyrosine phosphatase 1B.

Wiesmann C, Barr KJ, Kung J, Zhu J, Erlanson DA, Shen W, Fahr BJ, Zhong M, Taylor L, Randal M, McDowell RS, Hansen SK. Wiesmann C, et al. Among authors: erlanson da. Nat Struct Mol Biol. 2004 Aug;11(8):730-7. doi: 10.1038/nsmb803. Epub 2004 Jul 18. Nat Struct Mol Biol. 2004. PMID: 15258570

8

Selective reduction of peptide isothiazolidin-3-ones.

Shiau TP, Erlanson DA, Gordon EM. Shiau TP, et al. Among authors: erlanson da. Org Lett. 2006 Dec 7;8(25):5697-9. doi: 10.1021/ol062077j. Org Lett. 2006. PMID: 17134250

9

Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry.

Cancilla MT, He MM, Viswanathan N, Simmons RL, Taylor M, Fung AD, Cao K, Erlanson DA. Cancilla MT, et al. Among authors: erlanson da. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3978-81. doi: 10.1016/j.bmcl.2008.06.011. Epub 2008 Jun 10. Bioorg Med Chem Lett. 2008. PMID: 18579375

10

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.

Erlanson DA, Arndt JW, Cancilla MT, Cao K, Elling RA, English N, Friedman J, Hansen SK, Hession C, Joseph I, Kumaravel G, Lee WC, Lind KE, McDowell RS, Miatkowski K, Nguyen C, Nguyen TB, Park S, Pathan N, Penny DM, Romanowski MJ, Scott D, Silvian L, Simmons RL, Tangonan BT, Yang W, Sun L. Erlanson DA, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3078-83. doi: 10.1016/j.bmcl.2011.03.032. Epub 2011 Mar 17. Bioorg Med Chem Lett. 2011. PMID: 21459573

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