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Identification of potent and novel small-molecule inhibitors of caspase-3.
Allen DA, Pham P, Choong IC, Fahr B, Burdett MT, Lew W, DeLano WL, Gordon EM, Lam JW, O'Brien T, Lee D. Allen DA, et al. Among authors: pham p. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3651-5. doi: 10.1016/j.bmcl.2003.08.024. Bioorg Med Chem Lett. 2003. PMID: 14552750
Tethering identifies fragment that yields potent inhibitors of human caspase-1.
Fahr BT, O'Brien T, Pham P, Waal ND, Baskaran S, Raimundo BC, Lam JW, Sopko MM, Purkey HE, Romanowski MJ. Fahr BT, et al. Among authors: pham p. Bioorg Med Chem Lett. 2006 Feb;16(3):559-62. doi: 10.1016/j.bmcl.2005.10.048. Epub 2005 Nov 4. Bioorg Med Chem Lett. 2006. PMID: 16274992
Structural analysis of caspase-1 inhibitors derived from Tethering.
O'Brien T, Fahr BT, Sopko MM, Lam JW, Waal ND, Raimundo BC, Purkey HE, Pham P, Romanowski MJ. O'Brien T, et al. Among authors: pham p. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt 5):451-8. doi: 10.1107/S1744309105010109. Epub 2005 Apr 9. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16511067 Free PMC article.
Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Fucini RV, Hanan EJ, Romanowski MJ, Elling RA, Lew W, Barr KJ, Zhu J, Yoburn JC, Liu Y, Fahr BT, Fan J, Lu Y, Pham P, Choong IC, VanderPorten EC, Bui M, Purkey HE, Evanchik MJ, Yang W. Fucini RV, et al. Among authors: pham p. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5648-52. doi: 10.1016/j.bmcl.2008.08.095. Epub 2008 Aug 29. Bioorg Med Chem Lett. 2008. PMID: 18793847
Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.
Yang W, Fucini RV, Fahr BT, Randal M, Lind KE, Lam MB, Lu W, Lu Y, Cary DR, Romanowski MJ, Colussi D, Pietrak B, Allison TJ, Munshi SK, Penny DM, Pham P, Sun J, Thomas AE, Wilkinson JM, Jacobs JW, McDowell RS, Ballinger MD. Yang W, et al. Among authors: pham p. Biochemistry. 2009 Jun 2;48(21):4488-96. doi: 10.1021/bi900017q. Biochemistry. 2009. PMID: 19284778
875 results