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An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope.
Seifert U, Marañón C, Shmueli A, Desoutter JF, Wesoloski L, Janek K, Henklein P, Diescher S, Andrieu M, de la Salle H, Weinschenk T, Schild H, Laderach D, Galy A, Haas G, Kloetzel PM, Reiss Y, Hosmalin A. Seifert U, et al. Nat Immunol. 2003 Apr;4(4):375-9. doi: 10.1038/ni905. Epub 2003 Feb 24. Nat Immunol. 2003. PMID: 12598896
Hepatitis C virus mutation affects proteasomal epitope processing.
Seifert U, Liermann H, Racanelli V, Halenius A, Wiese M, Wedemeyer H, Ruppert T, Rispeter K, Henklein P, Sijts A, Hengel H, Kloetzel PM, Rehermann B. Seifert U, et al. J Clin Invest. 2004 Jul;114(2):250-9. doi: 10.1172/JCI20985. J Clin Invest. 2004. PMID: 15254592 Free PMC article.
Consequences of COP9 signalosome and 26S proteasome interaction.
Huang X, Hetfeld BK, Seifert U, Kähne T, Kloetzel PM, Naumann M, Bech-Otschir D, Dubiel W. Huang X, et al. Among authors: seifert u. FEBS J. 2005 Aug;272(15):3909-17. doi: 10.1111/j.1742-4658.2005.04807.x. FEBS J. 2005. PMID: 16045761 Free article.
The N-terminal flanking region of the TRP2360-368 melanoma antigen determines proteasome activator PA28 requirement for epitope liberation.
Textoris-Taube K, Henklein P, Pollmann S, Bergann T, Weisshoff H, Seifert U, Drung I, Mügge C, Sijts A, Kloetzel PM, Kuckelkorn U. Textoris-Taube K, et al. Among authors: seifert u. J Biol Chem. 2007 Apr 27;282(17):12749-54. doi: 10.1074/jbc.M611644200. Epub 2007 Feb 16. J Biol Chem. 2007. PMID: 17308306 Free article.
Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population.
Mishto M, Bellavista E, Ligorio C, Textoris-Taube K, Santoro A, Giordano M, D'Alfonso S, Listì F, Nacmias B, Cellini E, Leone M, Grimaldi LM, Fenoglio C, Esposito F, Martinelli-Boneschi F, Galimberti D, Scarpini E, Seifert U, Amato MP, Caruso C, Foschini MP, Kloetzel PM, Franceschi C. Mishto M, et al. Among authors: seifert u. PLoS One. 2010 Feb 18;5(2):e9287. doi: 10.1371/journal.pone.0009287. PLoS One. 2010. PMID: 20174631 Free PMC article.
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Kessler JH, Khan S, Seifert U, Le Gall S, Chow KM, Paschen A, Bres-Vloemans SA, de Ru A, van Montfoort N, Franken KL, Benckhuijsen WE, Brooks JM, van Hall T, Ray K, Mulder A, Doxiadis II, van Swieten PF, Overkleeft HS, Prat A, Tomkinson B, Neefjes J, Kloetzel PM, Rodgers DW, Hersh LB, Drijfhout JW, van Veelen PA, Ossendorp F, Melief CJ. Kessler JH, et al. Among authors: seifert u. Nat Immunol. 2011 Jan;12(1):45-53. doi: 10.1038/ni.1974. Epub 2010 Dec 12. Nat Immunol. 2011. PMID: 21151101
236 results