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Hints on the evolutionary design of a dimeric RNase with special bioactions.
Di Donato A, Cafaro V, Romeo I, D'Alessio G. Di Donato A, et al. Among authors: cafaro v. Protein Sci. 1995 Aug;4(8):1470-7. doi: 10.1002/pro.5560040804. Protein Sci. 1995. PMID: 8520472 Free PMC article.
Residues P19, L28, C31, and C32 have been implicated (Di Donato A, Cafaro V, D'Alessio G, 1994, J Biol Chem 269:17394-17396; Mazzarella L, Vitagliano L, Zagari A, 1995, Proc Natl Acad Sci USA: forthcoming) with key roles in determining the dimeric structure and the …
Residues P19, L28, C31, and C32 have been implicated (Di Donato A, Cafaro V, D'Alessio G, 1994, J Biol Chem 269:17394-17396; M …
New muteins of RNase A with enhanced antitumor action.
Cafaro V, Bracale A, Di Maro A, Sorrentino S, D'Alessio G, Di Donato A. Cafaro V, et al. FEBS Lett. 1998 Oct 16;437(1-2):149-52. doi: 10.1016/s0014-5793(98)01221-6. FEBS Lett. 1998. PMID: 9804190 Free article.
Monomeric bovine pancreatic RNase A has been transformed into a dimeric ribonuclease with antitumor activity (Di Donato, A., Cafaro, V. and D'Alessio, G. (1994) J. Biol. Chem. 269, 17394-17396). This was accomplished by replacing the residues located in the RNase ch …
Monomeric bovine pancreatic RNase A has been transformed into a dimeric ribonuclease with antitumor activity (Di Donato, A., Cafaro, …
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