Wolfe MS - Search Results

1

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

Micchelli CA, Esler WP, Kimberly WT, Jack C, Berezovska O, Kornilova A, Hyman BT, Perrimon N, Wolfe MS. Micchelli CA, et al. Among authors: wolfe ms. FASEB J. 2003 Jan;17(1):79-81. doi: 10.1096/fj.02-0394fje. Epub 2002 Nov 1. FASEB J. 2003. PMID: 12424225

2

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Wolfe MS, et al. Nature. 1999 Apr 8;398(6727):513-7. doi: 10.1038/19077. Nature. 1999. PMID: 10206644

3

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. De Strooper B, et al. Among authors: wolfe ms. Nature. 1999 Apr 8;398(6727):518-22. doi: 10.1038/19083. Nature. 1999. PMID: 10206645

4

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.

Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM. Ray WJ, et al. J Biol Chem. 1999 Dec 17;274(51):36801-7. doi: 10.1074/jbc.274.51.36801. J Biol Chem. 1999. PMID: 10593990 Free article.

5

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.

Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ. Kimberly WT, et al. Among authors: wolfe ms. J Biol Chem. 2000 Feb 4;275(5):3173-8. doi: 10.1074/jbc.275.5.3173. J Biol Chem. 2000. PMID: 10652302 Free article.

6

In search of gamma-secretase: presenilin at the cutting edge.

Selkoe DJ, Wolfe MS. Selkoe DJ, et al. Among authors: wolfe ms. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5690-2. doi: 10.1073/pnas.97.11.5690. Proc Natl Acad Sci U S A. 2000. PMID: 10823929 Free PMC article. No abstract available.

7

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Esler WP, et al. Among authors: wolfe ms. Nat Cell Biol. 2000 Jul;2(7):428-34. doi: 10.1038/35017062. Nat Cell Biol. 2000. PMID: 10878808

8

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.

Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Berezovska O, et al. Among authors: wolfe ms. J Neurochem. 2000 Aug;75(2):583-93. doi: 10.1046/j.1471-4159.2000.0750583.x. J Neurochem. 2000. PMID: 10899933 Free article.

9

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.

Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Xia W, et al. Among authors: wolfe ms. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9299-304. doi: 10.1073/pnas.97.16.9299. Proc Natl Acad Sci U S A. 2000. PMID: 10922078 Free PMC article.

10

FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.

Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ. Xia W, et al. Among authors: wolfe ms. Neurobiol Dis. 2000 Dec;7(6 Pt B):673-81. doi: 10.1006/nbdi.2000.0322. Neurobiol Dis. 2000. PMID: 11114265

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