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Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians.
Rasmussen SK, Urhammer SA, Berglund L, Jensen JN, Hansen L, Echwald SM, Borch-Johnsen K, Horikawa Y, Mashima H, Lithell H, Cox NJ, Hansen T, Bell GI, Pedersen O. Rasmussen SK, et al. Among authors: horikawa y. Diabetes. 2002 Dec;51(12):3561-7. doi: 10.2337/diabetes.51.12.3561. Diabetes. 2002. PMID: 12453914
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI. Horikawa Y, et al. Nat Genet. 2000 Oct;26(2):163-75. doi: 10.1038/79876. Nat Genet. 2000. PMID: 11017071
Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.
Weedon MN, Schwarz PE, Horikawa Y, Iwasaki N, Illig T, Holle R, Rathmann W, Selisko T, Schulze J, Owen KR, Evans J, Del Bosque-Plata L, Hitman G, Walker M, Levy JC, Sampson M, Bell GI, McCarthy MI, Hattersley AT, Frayling TM. Weedon MN, et al. Among authors: horikawa y. Am J Hum Genet. 2003 Nov;73(5):1208-12. doi: 10.1086/379285. Am J Hum Genet. 2003. PMID: 14574648 Free PMC article. No abstract available.
Calpain system regulates muscle mass and glucose transporter GLUT4 turnover.
Otani K, Han DH, Ford EL, Garcia-Roves PM, Ye H, Horikawa Y, Bell GI, Holloszy JO, Polonsky KS. Otani K, et al. Among authors: horikawa y. J Biol Chem. 2004 May 14;279(20):20915-20. doi: 10.1074/jbc.M400213200. Epub 2004 Mar 9. J Biol Chem. 2004. PMID: 15014085 Free article.
632 results