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The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state.
Clements CS, Kjer-Nielsen L, MacDonald WA, Brooks AG, Purcell AW, McCluskey J, Rossjohn J. Clements CS, et al. Among authors: macdonald wa. Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):2131-4. doi: 10.1107/s0907444902015482. Epub 2002 Nov 23. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 12454477
Specificity on a knife-edge: the alphabeta T cell receptor.
Clements CS, Dunstone MA, Macdonald WA, McCluskey J, Rossjohn J. Clements CS, et al. Among authors: macdonald wa. Curr Opin Struct Biol. 2006 Dec;16(6):787-95. doi: 10.1016/j.sbi.2006.09.004. Epub 2006 Sep 29. Curr Opin Struct Biol. 2006. PMID: 17011774 Review.
Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion.
Zernich D, Purcell AW, Macdonald WA, Kjer-Nielsen L, Ely LK, Laham N, Crockford T, Mifsud NA, Bharadwaj M, Chang L, Tait BD, Holdsworth R, Brooks AG, Bottomley SP, Beddoe T, Peh CA, Rossjohn J, McCluskey J. Zernich D, et al. Among authors: macdonald wa. J Exp Med. 2004 Jul 5;200(1):13-24. doi: 10.1084/jem.20031680. Epub 2004 Jun 28. J Exp Med. 2004. PMID: 15226359 Free PMC article.
T cell allorecognition and MHC restriction--A case of Jekyll and Hyde?
Archbold JK, Ely LK, Kjer-Nielsen L, Burrows SR, Rossjohn J, McCluskey J, Macdonald WA. Archbold JK, et al. Among authors: macdonald wa. Mol Immunol. 2008 Feb;45(3):583-98. doi: 10.1016/j.molimm.2006.05.018. Epub 2007 Sep 14. Mol Immunol. 2008. PMID: 17869342 Review.
T-cell allorecognition: a case of mistaken identity or déjà vu?
Archbold JK, Macdonald WA, Burrows SR, Rossjohn J, McCluskey J. Archbold JK, et al. Among authors: macdonald wa. Trends Immunol. 2008 May;29(5):220-6. doi: 10.1016/j.it.2008.02.005. Epub 2008 Apr 18. Trends Immunol. 2008. PMID: 18378495 Review.
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
Beddoe T, Chen Z, Clements CS, Ely LK, Bushell SR, Vivian JP, Kjer-Nielsen L, Pang SS, Dunstone MA, Liu YC, Macdonald WA, Perugini MA, Wilce MC, Burrows SR, Purcell AW, Tiganis T, Bottomley SP, McCluskey J, Rossjohn J. Beddoe T, et al. Among authors: macdonald wa. Immunity. 2009 Jun 19;30(6):777-88. doi: 10.1016/j.immuni.2009.03.018. Epub 2009 May 21. Immunity. 2009. PMID: 19464197 Free article.
T cell allorecognition via molecular mimicry.
Macdonald WA, Chen Z, Gras S, Archbold JK, Tynan FE, Clements CS, Bharadwaj M, Kjer-Nielsen L, Saunders PM, Wilce MC, Crawford F, Stadinsky B, Jackson D, Brooks AG, Purcell AW, Kappler JW, Burrows SR, Rossjohn J, McCluskey J. Macdonald WA, et al. Immunity. 2009 Dec 18;31(6):897-908. doi: 10.1016/j.immuni.2009.09.025. Immunity. 2009. PMID: 20064448 Free article.
69 results