Nitration and inactivation of cytochrome P450BM-3 by peroxynitrite. Stopped-flow measurements prove ferryl intermediates.
Daiber A, Herold S, Schöneich C, Namgaladze D, Peterson JA, Ullrich V.
Daiber A, et al. Among authors: ullrich v.
Eur J Biochem. 2000 Dec;267(23):6729-39. doi: 10.1046/j.1432-1033.2000.01768.x.
Eur J Biochem. 2000.
PMID: 11082183
Free article.
We have previously shown that prostacyclin synthase, a heme-thiolate enzyme essential for regulation of vascular tone, is nitrated and inactivated by submicromolar concentrations of PN [Zou, M.-H. & Ullrich, V. (1996) FEBS Lett. 382, 101-104] and we have studied …
We have previously shown that prostacyclin synthase, a heme-thiolate enzyme essential for regulation of vascular tone, is nitrated and inact …