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Vaccination of cattle with a virus vector vaccine against a major membrane protein of Mycobacterium avium subsp. paratuberculosis elicits CD8 cytotoxic T cells that kill intracellular bacteria.
Mahmoud AH, Abdellrazeq GS, Franceschi V, Schneider DA, Bannantine JP, Fry LM, Hulubei V, De Matteis G, Park KT, Minesso S, Davis WC, Donofrio G. Mahmoud AH, et al. Among authors: hulubei v. Vet Immunol Immunopathol. 2024 Sep;275:110814. doi: 10.1016/j.vetimm.2024.110814. Epub 2024 Aug 12. Vet Immunol Immunopathol. 2024. PMID: 39142123
Comparative analysis of the specificity of monoclonal antibodies developed against the bottlenose dolphin, Tursiops truncatus, TNF-α, IL1-β, IL-6, IL-8, IL-10 with monoclonal antibodies made against ovine IFN-γ bovine IL-17A and IL-1β revealed they recognize epitopes conserved on dolphin and bovine orthologues.
Elnaggar MM, Abdellrazeq GS, Sacco RE, Harsla TR, Mucci ML, Fry LM, Hulubei V, Davis WC. Elnaggar MM, et al. Among authors: hulubei v. Vet Immunol Immunopathol. 2022 Aug;250:110456. doi: 10.1016/j.vetimm.2022.110456. Epub 2022 Jun 17. Vet Immunol Immunopathol. 2022. PMID: 35728348
Advances in Understanding of the Immune Response to Mycobacterial Pathogens and Vaccines through Use of Cattle and Mycobacterium avium subsp. paratuberculosis as a Prototypic Mycobacterial Pathogen.
Davis WC, Abdellrazeq GS, Mahmoud AH, Park KT, Elnaggar MM, Donofrio G, Hulubei V, Fry LM. Davis WC, et al. Among authors: hulubei v. Vaccines (Basel). 2021 Sep 26;9(10):1085. doi: 10.3390/vaccines9101085. Vaccines (Basel). 2021. PMID: 34696193 Free PMC article. Review.
relA is Achilles' heel for mycobacterial pathogens as demonstrated with deletion mutants in Mycobacterium avium subsp. paratuberculosis and mycobacterium bovis bacillus Calmette-Guérin (BCG).
Abdellrazeq GS, Mahmoud AH, Park KT, Fry LM, Elnaggar MM, Schneider DA, Hulubei V, Davis WC. Abdellrazeq GS, et al. Among authors: hulubei v. Tuberculosis (Edinb). 2020 Jan;120:101904. doi: 10.1016/j.tube.2020.101904. Epub 2020 Jan 15. Tuberculosis (Edinb). 2020. PMID: 32090858
Capacity to Elicit Cytotoxic CD8 T Cell Activity Against Mycobacterium avium subsp. paratuberculosis Is Retained in a Vaccine Candidate 35 kDa Peptide Modified for Expression in Mammalian Cells.
Franceschi V, Mahmoud AH, Abdellrazeq GS, Tebaldi G, Macchi F, Russo L, Fry LM, Elnaggar MM, Bannantine JP, Park KT, Hulubei V, Cavirani S, Davis WC, Donofrio G. Franceschi V, et al. Among authors: hulubei v. Front Immunol. 2019 Dec 11;10:2859. doi: 10.3389/fimmu.2019.02859. eCollection 2019. Front Immunol. 2019. PMID: 31921129 Free PMC article.
17 results