Diehl T - Search Results

1

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS. Kimberly WT, et al. Among authors: diehl t. Biochemistry. 2003 Jan 14;42(1):137-44. doi: 10.1021/bi026888g. Biochemistry. 2003. PMID: 12515548

2

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.

Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS. Esler WP, et al. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2720-5. doi: 10.1073/pnas.052436599. Epub 2002 Feb 26. Proc Natl Acad Sci U S A. 2002. PMID: 11867728 Free PMC article.

3

Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs.

Sato T, Nyborg AC, Iwata N, Diehl TS, Saido TC, Golde TE, Wolfe MS. Sato T, et al. Among authors: diehl ts. Biochemistry. 2006 Jul 18;45(28):8649-56. doi: 10.1021/bi060597g. Biochemistry. 2006. PMID: 16834339

4

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Wolfe MS, et al. Among authors: diehl ts. Nature. 1999 Apr 8;398(6727):513-7. doi: 10.1038/19077. Nature. 1999. PMID: 10206644

5

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Esler WP, et al. Among authors: diehl ts. Nat Cell Biol. 2000 Jul;2(7):428-34. doi: 10.1038/35017062. Nat Cell Biol. 2000. PMID: 10878808

6

Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.

Esler WP, Das C, Campbell WA, Kimberly WT, Kornilova AY, Diehl TS, Ye W, Ostaszewski BL, Xia W, Selkoe DJ, Wolfe MS. Esler WP, et al. Nat Cell Biol. 2002 May;4(5):E110-1; author reply E111-2. doi: 10.1038/ncb0502-e110b. Nat Cell Biol. 2002. PMID: 11988746 No abstract available.

7

Designed helical peptides inhibit an intramembrane protease.

Das C, Berezovska O, Diehl TS, Genet C, Buldyrev I, Tsai JY, Hyman BT, Wolfe MS. Das C, et al. Among authors: diehl ts. J Am Chem Soc. 2003 Oct 1;125(39):11794-5. doi: 10.1021/ja037131v. J Am Chem Soc. 2003. PMID: 14505382

8

Active gamma-secretase complexes contain only one of each component.

Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Sato T, et al. Among authors: diehl ts. J Biol Chem. 2007 Nov 23;282(47):33985-93. doi: 10.1074/jbc.M705248200. Epub 2007 Oct 2. J Biol Chem. 2007. PMID: 17911105 Free article.

9

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.

Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ. Citron M, et al. Among authors: diehl t. Nat Med. 1997 Jan;3(1):67-72. doi: 10.1038/nm0197-67. Nat Med. 1997. PMID: 8986743

10

Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.

Citron M, Diehl TS, Capell A, Haass C, Teplow DB, Selkoe DJ. Citron M, et al. Among authors: diehl ts. Neuron. 1996 Jul;17(1):171-9. doi: 10.1016/s0896-6273(00)80290-1. Neuron. 1996. PMID: 8755488 Free article.

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