Esler WP - Search Results

1

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS. Kimberly WT, et al. Among authors: esler wp. Biochemistry. 2003 Jan 14;42(1):137-44. doi: 10.1021/bi026888g. Biochemistry. 2003. PMID: 12515548

2

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.

Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS. Esler WP, et al. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2720-5. doi: 10.1073/pnas.052436599. Epub 2002 Feb 26. Proc Natl Acad Sci U S A. 2002. PMID: 11867728 Free PMC article.

3

Continuing strategies for inhibiting Alzheimer's gamma-secretase.

Wolfe MS, Esler WP, Das C. Wolfe MS, et al. Among authors: esler wp. J Mol Neurosci. 2002 Aug-Oct;19(1-2):83-7. doi: 10.1007/s12031-002-0015-5. J Mol Neurosci. 2002. PMID: 12212799

4

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

Micchelli CA, Esler WP, Kimberly WT, Jack C, Berezovska O, Kornilova A, Hyman BT, Perrimon N, Wolfe MS. Micchelli CA, et al. Among authors: esler wp. FASEB J. 2003 Jan;17(1):79-81. doi: 10.1096/fj.02-0394fje. Epub 2002 Nov 1. FASEB J. 2003. PMID: 12424225

5

Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics.

Esler WP, Das C, Wolfe MS. Esler WP, et al. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1935-8. doi: 10.1016/j.bmcl.2004.01.077. Bioorg Med Chem Lett. 2004. PMID: 15050631

6

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Esler WP, et al. Nat Cell Biol. 2000 Jul;2(7):428-34. doi: 10.1038/35017062. Nat Cell Biol. 2000. PMID: 10878808

7

A portrait of Alzheimer secretases--new features and familiar faces.

Esler WP, Wolfe MS. Esler WP, et al. Science. 2001 Aug 24;293(5534):1449-54. doi: 10.1126/science.1064638. Science. 2001. PMID: 11520976 Review.

8

Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.

Esler WP, Das C, Campbell WA, Kimberly WT, Kornilova AY, Diehl TS, Ye W, Ostaszewski BL, Xia W, Selkoe DJ, Wolfe MS. Esler WP, et al. Nat Cell Biol. 2002 May;4(5):E110-1; author reply E111-2. doi: 10.1038/ncb0502-e110b. Nat Cell Biol. 2002. PMID: 11988746 No abstract available.

9

Point substitution in the central hydrophobic cluster of a human beta-amyloid congener disrupts peptide folding and abolishes plaque competence.

Esler WP, Stimson ER, Ghilardi JR, Lu YA, Felix AM, Vinters HV, Mantyh PW, Lee JP, Maggio JE. Esler WP, et al. Biochemistry. 1996 Nov 5;35(44):13914-21. doi: 10.1021/bi961302+. Biochemistry. 1996. PMID: 8909288

10

In vitro growth of Alzheimer's disease beta-amyloid plaques displays first-order kinetics.

Esler WP, Stimson ER, Ghilardi JR, Vinters HV, Lee JP, Mantyh PW, Maggio JE. Esler WP, et al. Biochemistry. 1996 Jan 23;35(3):749-57. doi: 10.1021/bi951685w. Biochemistry. 1996. PMID: 8547255

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