Ye W - Search Results

1

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS. Kimberly WT, et al. Among authors: ye w. Biochemistry. 2003 Jan 14;42(1):137-44. doi: 10.1021/bi026888g. Biochemistry. 2003. PMID: 12515548

2

Discovery of notch-sparing gamma-secretase inhibitors.

Augelli-Szafran CE, Wei HX, Lu D, Zhang J, Gu Y, Yang T, Osenkowski P, Ye W, Wolfe MS. Augelli-Szafran CE, et al. Among authors: ye w. Curr Alzheimer Res. 2010 May;7(3):207-9. doi: 10.2174/156720510791050920. Curr Alzheimer Res. 2010. PMID: 20088802 Free PMC article. Review.

3

Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides.

Zhang J, Ye W, Wang R, Wolfe MS, Greenberg BD, Selkoe DJ. Zhang J, et al. Among authors: ye w. J Biol Chem. 2002 Apr 26;277(17):15069-75. doi: 10.1074/jbc.M105375200. Epub 2002 Feb 11. J Biol Chem. 2002. PMID: 11839734 Free article.

4

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.

Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS. Esler WP, et al. Among authors: ye w. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2720-5. doi: 10.1073/pnas.052436599. Epub 2002 Feb 26. Proc Natl Acad Sci U S A. 2002. PMID: 11867728 Free PMC article.

5

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation.

Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Kimberly WT, et al. Among authors: ye w. J Biol Chem. 2002 Sep 20;277(38):35113-7. doi: 10.1074/jbc.M204446200. Epub 2002 Jul 18. J Biol Chem. 2002. PMID: 12130643 Free article.

6

Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.

Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Kimberly WT, et al. Among authors: ye w. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6382-7. doi: 10.1073/pnas.1037392100. Epub 2003 May 9. Proc Natl Acad Sci U S A. 2003. PMID: 12740439 Free PMC article.

7

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.

LaVoie MJ, Fraering PC, Ostaszewski BL, Ye W, Kimberly WT, Wolfe MS, Selkoe DJ. LaVoie MJ, et al. Among authors: ye w. J Biol Chem. 2003 Sep 26;278(39):37213-22. doi: 10.1074/jbc.M303941200. Epub 2003 Jul 11. J Biol Chem. 2003. PMID: 12857757 Free article.

8

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.

Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS. Fraering PC, et al. Among authors: ye w. Biochemistry. 2004 Jan 20;43(2):323-33. doi: 10.1021/bi035748j. Biochemistry. 2004. PMID: 14717586

9

Purification and characterization of the human gamma-secretase complex.

Fraering PC, Ye W, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL, van Dorsselaer A, Wang R, Selkoe DJ, Wolfe MS. Fraering PC, et al. Among authors: ye w. Biochemistry. 2004 Aug 3;43(30):9774-89. doi: 10.1021/bi0494976. Biochemistry. 2004. PMID: 15274632

10

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site.

Fraering PC, Ye W, LaVoie MJ, Ostaszewski BL, Selkoe DJ, Wolfe MS. Fraering PC, et al. Among authors: ye w. J Biol Chem. 2005 Dec 23;280(51):41987-96. doi: 10.1074/jbc.M501368200. Epub 2005 Oct 19. J Biol Chem. 2005. PMID: 16236717 Free PMC article.

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