Gouaux E - Search Results

1

Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.

Hogner A, Greenwood JR, Liljefors T, Lunn ML, Egebjerg J, Larsen IK, Gouaux E, Kastrup JS. Hogner A, et al. Among authors: gouaux e. J Med Chem. 2003 Jan 16;46(2):214-21. doi: 10.1021/jm020989v. J Med Chem. 2003. PMID: 12519060

Comparison with the only previous structure of the ligand-binding core in complex with an antagonist, 6,7-dinitro-2,3-quinoxalinedione (DNQX) (Armstrong, N.; Gouaux, E. Neuron 2000, 28, 165-181), reveals that ATPO and DNQX stabilize an open form of the ligand-bindin …

Comparison with the only previous structure of the ligand-binding core in complex with an antagonist, 6,7-dinitro-2,3-quinoxalinedione (DNQX …

2

Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.

Hogner A, Kastrup JS, Jin R, Liljefors T, Mayer ML, Egebjerg J, Larsen IK, Gouaux E. Hogner A, et al. Among authors: gouaux e. J Mol Biol. 2002 Sep 6;322(1):93-109. doi: 10.1016/s0022-2836(02)00650-2. J Mol Biol. 2002. PMID: 12215417

3

GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists.

Kasper C, Lunn ML, Liljefors T, Gouaux E, Egebjerg J, Kastrup JS. Kasper C, et al. Among authors: gouaux e. FEBS Lett. 2002 Nov 6;531(2):173-8. doi: 10.1016/s0014-5793(02)03496-8. FEBS Lett. 2002. PMID: 12417307 Free article.

4

Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity.

Lunn ML, Hogner A, Stensbøl TB, Gouaux E, Egebjerg J, Kastrup JS. Lunn ML, et al. Among authors: gouaux e. J Med Chem. 2003 Feb 27;46(5):872-5. doi: 10.1021/jm021020+. J Med Chem. 2003. PMID: 12593667

5

Structure of a glutamate-receptor ligand-binding core in complex with kainate.

Armstrong N, Sun Y, Chen GQ, Gouaux E. Armstrong N, et al. Among authors: gouaux e. Nature. 1998 Oct 29;395(6705):913-7. doi: 10.1038/27692. Nature. 1998. PMID: 9804426

6

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.

Armstrong N, Gouaux E. Armstrong N, et al. Among authors: gouaux e. Neuron. 2000 Oct;28(1):165-81. doi: 10.1016/s0896-6273(00)00094-5. Neuron. 2000. PMID: 11086992 Free article.

7

Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal.

Jin R, Gouaux E. Jin R, et al. Among authors: gouaux e. Biochemistry. 2003 May 13;42(18):5201-13. doi: 10.1021/bi020632t. Biochemistry. 2003. PMID: 12731861

8

Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core.

Furukawa H, Gouaux E. Furukawa H, et al. Among authors: gouaux e. EMBO J. 2003 Jun 16;22(12):2873-85. doi: 10.1093/emboj/cdg303. EMBO J. 2003. PMID: 12805203 Free PMC article.

9

Structure and function of AMPA receptors.

Gouaux E. Gouaux E. J Physiol. 2004 Jan 15;554(Pt 2):249-53. doi: 10.1113/jphysiol.2003.054320. Epub 2003 Nov 28. J Physiol. 2004. PMID: 14645452 Free PMC article. Review.

10

Crystal structure and association behaviour of the GluR2 amino-terminal domain.

Jin R, Singh SK, Gu S, Furukawa H, Sobolevsky AI, Zhou J, Jin Y, Gouaux E. Jin R, et al. Among authors: gouaux e. EMBO J. 2009 Jun 17;28(12):1812-23. doi: 10.1038/emboj.2009.140. Epub 2009 May 21. EMBO J. 2009. PMID: 19461580 Free PMC article.

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