Wypych J - Search Results

1

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.

Krishnan S, Chi EY, Wood SJ, Kendrick BS, Li C, Garzon-Rodriguez W, Wypych J, Randolph TW, Narhi LO, Biere AL, Citron M, Carpenter JF. Krishnan S, et al. Among authors: wypych j. Biochemistry. 2003 Jan 28;42(3):829-37. doi: 10.1021/bi026528t. Biochemistry. 2003. PMID: 12534296

2

Changes in conformation and stability upon SCF/sKit complex formation.

Narhi LO, Wypych J, Li T, Langley KE, Arakawa T. Narhi LO, et al. Among authors: wypych j. J Protein Chem. 1998 Jul;17(5):387-96. doi: 10.1023/a:1022551832443. J Protein Chem. 1998. PMID: 9717735

3

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation.

Narhi L, Wood SJ, Steavenson S, Jiang Y, Wu GM, Anafi D, Kaufman SA, Martin F, Sitney K, Denis P, Louis JC, Wypych J, Biere AL, Citron M. Narhi L, et al. Among authors: wypych j. J Biol Chem. 1999 Apr 2;274(14):9843-6. doi: 10.1074/jbc.274.14.9843. J Biol Chem. 1999. PMID: 10092675 Free article.

4

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease.

Wood SJ, Wypych J, Steavenson S, Louis JC, Citron M, Biere AL. Wood SJ, et al. Among authors: wypych j. J Biol Chem. 1999 Jul 9;274(28):19509-12. doi: 10.1074/jbc.274.28.19509. J Biol Chem. 1999. PMID: 10391881 Free article.

5

Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs.

Biere AL, Wood SJ, Wypych J, Steavenson S, Jiang Y, Anafi D, Jacobsen FW, Jarosinski MA, Wu GM, Louis JC, Martin F, Narhi LO, Citron M. Biere AL, et al. Among authors: wypych j. J Biol Chem. 2000 Nov 3;275(44):34574-9. doi: 10.1074/jbc.M005514200. J Biol Chem. 2000. PMID: 10942772 Free article.

6

Classification and characterization of therapeutic antibody aggregates.

Joubert MK, Luo Q, Nashed-Samuel Y, Wypych J, Narhi LO. Joubert MK, et al. Among authors: wypych j. J Biol Chem. 2011 Jul 15;286(28):25118-33. doi: 10.1074/jbc.M110.160457. Epub 2011 Mar 25. J Biol Chem. 2011. PMID: 21454532 Free PMC article.

Chemical modifications were also identified in a separate report (Luo, Q., Joubert, M. K., Stevenson, R., Narhi, L. O., and Wypych, J. (2011) J. Biol. Chem. 286, 25134-25144). Aggregates were categorized into seven discrete classes, based on the traits descri …

Chemical modifications were also identified in a separate report (Luo, Q., Joubert, M. K., Stevenson, R., Narhi, L. O., and Wypych, …

7

Chemical modifications in therapeutic protein aggregates generated under different stress conditions.

Luo Q, Joubert MK, Stevenson R, Ketchem RR, Narhi LO, Wypych J. Luo Q, et al. Among authors: wypych j. J Biol Chem. 2011 Jul 15;286(28):25134-44. doi: 10.1074/jbc.M110.160440. Epub 2011 Apr 25. J Biol Chem. 2011. PMID: 21518762 Free PMC article.

In a separate study, additional biophysical characterization was performed to arrange these aggregates into a classification system (Joubert, M. K., Luo, Q., Nashed-Samuel, Y., Wypych, J., and Narhi, L. O. (2011) J. Biol. Chem. 286, 25118-25133). Here, we rep …

In a separate study, additional biophysical characterization was performed to arrange these aggregates into a classification system (Joubert …

8

The majority of stem cell factor exists as monomer under physiological conditions. Implications for dimerization mediating biological activity.

Hsu YR, Wu GM, Mendiaz EA, Syed R, Wypych J, Toso R, Mann MB, Boone TC, Narhi LO, Lu HS, Langley KE. Hsu YR, et al. Among authors: wypych j. J Biol Chem. 1997 Mar 7;272(10):6406-15. doi: 10.1074/jbc.272.10.6406. J Biol Chem. 1997. PMID: 9045664 Free article.

9

Quantification of protein posttranslational modifications using stable isotope and mass spectrometry. II. Performance.

Luo Q, Wypych J, Jiang XG, Zhang X, Luo S, Jerums M, Lewis J, Keener R III, Huang G, Apostol I. Luo Q, et al. Among authors: wypych j. Anal Biochem. 2012 Feb 15;421(2):517-25. doi: 10.1016/j.ab.2011.12.003. Epub 2011 Dec 9. Anal Biochem. 2012. PMID: 22227056

10

In vitro stoichiometry of complexes between the soluble RANK ligand and the monoclonal antibody denosumab.

Arthur KK, Gabrielson JP, Hawkins N, Anafi D, Wypych J, Nagi A, Sullivan JK, Bondarenko PV. Arthur KK, et al. Among authors: wypych j. Biochemistry. 2012 Jan 24;51(3):795-806. doi: 10.1021/bi2007806. Epub 2012 Jan 12. Biochemistry. 2012. PMID: 22242921

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