Lebel LA - Search Results

1

Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum.

Wheeler VC, Lebel LA, Vrbanac V, Teed A, te Riele H, MacDonald ME. Wheeler VC, et al. Among authors: lebel la. Hum Mol Genet. 2003 Feb 1;12(3):273-81. doi: 10.1093/hmg/ddg056. Hum Mol Genet. 2003. PMID: 12554681

2

Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice.

Wheeler VC, Gutekunst CA, Vrbanac V, Lebel LA, Schilling G, Hersch S, Friedlander RM, Gusella JF, Vonsattel JP, Borchelt DR, MacDonald ME. Wheeler VC, et al. Among authors: lebel la. Hum Mol Genet. 2002 Mar 15;11(6):633-40. doi: 10.1093/hmg/11.6.633. Hum Mol Genet. 2002. PMID: 11912178

3

Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice.

Fossale E, Wheeler VC, Vrbanac V, Lebel LA, Teed A, Mysore JS, Gusella JF, MacDonald ME, Persichetti F. Fossale E, et al. Among authors: lebel la. Hum Mol Genet. 2002 Sep 15;11(19):2233-41. doi: 10.1093/hmg/11.19.2233. Hum Mol Genet. 2002. PMID: 12217951

4

Cln3(Deltaex7/8) knock-in mice with the common JNCL mutation exhibit progressive neurologic disease that begins before birth.

Cotman SL, Vrbanac V, Lebel LA, Lee RL, Johnson KA, Donahue LR, Teed AM, Antonellis K, Bronson RT, Lerner TJ, MacDonald ME. Cotman SL, et al. Among authors: lebel la. Hum Mol Genet. 2002 Oct 15;11(22):2709-21. doi: 10.1093/hmg/11.22.2709. Hum Mol Genet. 2002. PMID: 12374761

5

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists.

O'Donnell CJ, Peng L, O'Neill BT, Arnold EP, Mather RJ, Sands SB, Shrikhande A, Lebel LA, Spracklin DK, Nedza FM. O'Donnell CJ, et al. Among authors: lebel la. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4747-51. doi: 10.1016/j.bmcl.2009.06.059. Epub 2009 Jun 17. Bioorg Med Chem Lett. 2009. PMID: 19576766

6

Deconstructing cytisine: The syntheses of (+/-)-cyfusine and (+/-)-cyclopropylcyfusine, fused ring analogs of cytisine.

Yohannes D, Procko K, Lebel LA, Fox CB, O'Neill BT. Yohannes D, et al. Among authors: lebel la. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2316-9. doi: 10.1016/j.bmcl.2008.02.078. Epub 2008 Mar 6. Bioorg Med Chem Lett. 2008. PMID: 18356044

7

Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia.

Schmidt CJ, Chapin DS, Cianfrogna J, Corman ML, Hajos M, Harms JF, Hoffman WE, Lebel LA, McCarthy SA, Nelson FR, Proulx-LaFrance C, Majchrzak MJ, Ramirez AD, Schmidt K, Seymour PA, Siuciak JA, Tingley FD 3rd, Williams RD, Verhoest PR, Menniti FS. Schmidt CJ, et al. Among authors: lebel la. J Pharmacol Exp Ther. 2008 May;325(2):681-90. doi: 10.1124/jpet.107.132910. Epub 2008 Feb 20. J Pharmacol Exp Ther. 2008. PMID: 18287214

8

Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors.

Chappie TA, Humphrey JM, Allen MP, Estep KG, Fox CB, Lebel LA, Liras S, Marr ES, Menniti FS, Pandit J, Schmidt CJ, Tu M, Williams RD, Yang FV. Chappie TA, et al. Among authors: lebel la. J Med Chem. 2007 Jan 25;50(2):182-5. doi: 10.1021/jm060653b. J Med Chem. 2007. PMID: 17228859

9

Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid.

Rollema H, Chambers LK, Coe JW, Glowa J, Hurst RS, Lebel LA, Lu Y, Mansbach RS, Mather RJ, Rovetti CC, Sands SB, Schaeffer E, Schulz DW, Tingley FD 3rd, Williams KE. Rollema H, et al. Among authors: lebel la. Neuropharmacology. 2007 Mar;52(3):985-94. doi: 10.1016/j.neuropharm.2006.10.016. Epub 2006 Dec 8. Neuropharmacology. 2007. PMID: 17157884

10

Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis.

Siuciak JA, Chapin DS, Harms JF, Lebel LA, McCarthy SA, Chambers L, Shrikhande A, Wong S, Menniti FS, Schmidt CJ. Siuciak JA, et al. Among authors: lebel la. Neuropharmacology. 2006 Aug;51(2):386-96. doi: 10.1016/j.neuropharm.2006.04.013. Epub 2006 Jun 15. Neuropharmacology. 2006. PMID: 16780899

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