Le XF - Search Results

1

Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis.

Le XF, Hittelman WN, Liu J, McWatters A, Li C, Mills GB, Bast RC Jr. Le XF, et al. Oncogene. 2003 Jan 30;22(4):484-97. doi: 10.1038/sj.onc.1206175. Oncogene. 2003. PMID: 12555062

2

HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways.

Le XF, Pruefer F, Bast RC Jr. Le XF, et al. Cell Cycle. 2005 Jan;4(1):87-95. doi: 10.4161/cc.4.1.1360. Epub 2005 Jan 10. Cell Cycle. 2005. PMID: 15611642 Review.

3

Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells.

Le XF, Arachchige-Don AS, Mao W, Horne MC, Bast RC Jr. Le XF, et al. Mol Cancer Ther. 2007 Nov;6(11):2843-57. doi: 10.1158/1535-7163.MCT-07-0109. Mol Cancer Ther. 2007. PMID: 18025271

4

Src family kinases and paclitaxel sensitivity.

Le XF, Bast RC Jr. Le XF, et al. Cancer Biol Ther. 2011 Aug 15;12(4):260-9. doi: 10.4161/cbt.12.4.16430. Epub 2011 Aug 15. Cancer Biol Ther. 2011. PMID: 21646863 Free PMC article. Review.

5

The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition.

Le XF, Claret FX, Lammayot A, Tian L, Deshpande D, LaPushin R, Tari AM, Bast RC Jr. Le XF, et al. J Biol Chem. 2003 Jun 27;278(26):23441-50. doi: 10.1074/jbc.M300848200. Epub 2003 Apr 16. J Biol Chem. 2003. PMID: 12700233 Free article.

6

Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.

Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC Jr. Le XF, et al. J Biol Chem. 2005 Jan 21;280(3):2092-104. doi: 10.1074/jbc.M403080200. Epub 2004 Oct 25. J Biol Chem. 2005. PMID: 15504738 Free article.

7

Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway.

Le XF, Bedrosian I, Mao W, Murray M, Lu Z, Keyomarsi K, Lee MH, Zhao J, Bast RC Jr. Le XF, et al. Cell Cycle. 2006 Aug;5(15):1654-61. doi: 10.4161/cc.5.15.3007. Epub 2006 Aug 1. Cell Cycle. 2006. PMID: 16861913

8

Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2.

Le XF, Mao W, Lu C, Thornton A, Heymach JV, Sood AK, Bast RC Jr. Le XF, et al. Cell Cycle. 2008 Dec;7(23):3747-58. doi: 10.4161/cc.7.23.7212. Epub 2008 Dec 16. Cell Cycle. 2008. PMID: 19029832 Free PMC article.

9

Dasatinib induces autophagic cell death in human ovarian cancer.

Le XF, Mao W, Lu Z, Carter BZ, Bast RC Jr. Le XF, et al. Cancer. 2010 Nov 1;116(21):4980-90. doi: 10.1002/cncr.25426. Cancer. 2010. PMID: 20629079 Free PMC article.

10

SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer.

Ahmed AA, Lu Z, Jennings NB, Etemadmoghadam D, Capalbo L, Jacamo RO, Barbosa-Morais N, Le XF; Australian Ovarian Cancer Study Group; Vivas-Mejia P, Lopez-Berestein G, Grandjean G, Bartholomeusz G, Liao W, Andreeff M, Bowtell D, Glover DM, Sood AK, Bast RC Jr. Ahmed AA, et al. Among authors: le xf. Cancer Cell. 2010 Aug 9;18(2):109-21. doi: 10.1016/j.ccr.2010.06.018. Cancer Cell. 2010. PMID: 20708153 Free PMC article.

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