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Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET.
Fujita M, Ichise M, van Dyck CH, Zoghbi SS, Tamagnan G, Mukhin AG, Bozkurt A, Seneca N, Tipre D, DeNucci CC, Iida H, Vaupel DB, Horti AG, Koren AO, Kimes AS, London ED, Seibyl JP, Baldwin RM, Innis RB. Fujita M, et al. Among authors: kimes as. Eur J Nucl Med Mol Imaging. 2003 Dec;30(12):1620-9. doi: 10.1007/s00259-003-1320-0. Epub 2003 Oct 2. Eur J Nucl Med Mol Imaging. 2003. PMID: 14523584 Clinical Trial.
5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for alpha4beta2 nicotinic acetylcholine receptor and wide range of lipophilicity: potential probes for imaging with positron emission tomography.
Zhang Y, Pavlova OA, Chefer SI, Hall AW, Kurian V, Brown LL, Kimes AS, Mukhin AG, Horti AG. Zhang Y, et al. Among authors: kimes as. J Med Chem. 2004 May 6;47(10):2453-65. doi: 10.1021/jm030432v. J Med Chem. 2004. PMID: 15115389
Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography.
Vaupel DB, Tella SR, Huso DL, Wagner VO 3rd, Mukhin AG, Chefer SI, Horti AG, London ED, Koren AO, Kimes AS. Vaupel DB, et al. Among authors: kimes as. J Pharmacol Exp Ther. 2005 Jan;312(1):355-65. doi: 10.1124/jpet.104.073999. Epub 2004 Aug 26. J Pharmacol Exp Ther. 2005. PMID: 15331657
65 results