Weitz-Schmidt G - Search Results

1

1,4-Diazepane-2-ones as novel inhibitors of LFA-1.

Wattanasin S, Albert R, Ehrhardt C, Roche D, Sabio M, Hommel U, Welzenbach K, Weitz-Schmidt G. Wattanasin S, et al. Bioorg Med Chem Lett. 2003 Feb 10;13(3):499-502. doi: 10.1016/s0960-894x(02)00991-5. Bioorg Med Chem Lett. 2003. PMID: 12565959

2

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.

Kallen J, Welzenbach K, Ramage P, Geyl D, Kriwacki R, Legge G, Cottens S, Weitz-Schmidt G, Hommel U. Kallen J, et al. J Mol Biol. 1999 Sep 10;292(1):1-9. doi: 10.1006/jmbi.1999.3047. J Mol Biol. 1999. PMID: 10493852

3

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site.

Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens S, Takada Y, Hommel U. Weitz-Schmidt G, et al. Nat Med. 2001 Jun;7(6):687-92. doi: 10.1038/89058. Nat Med. 2001. PMID: 11385505

4

A homogeneous fluorometric assay for measuring cell adhesion to immobilized ligand using V-well microtiter plates.

Weetall M, Hugo R, Friedman C, Maida S, West S, Wattanasin S, Bouhel R, Weitz-Schmidt G, Lake P. Weetall M, et al. Anal Biochem. 2001 Jun 15;293(2):277-87. doi: 10.1006/abio.2001.5140. Anal Biochem. 2001. PMID: 11399044

5

Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition.

Welzenbach K, Hommel U, Weitz-Schmidt G. Welzenbach K, et al. J Biol Chem. 2002 Mar 22;277(12):10590-8. doi: 10.1074/jbc.M110521200. Epub 2002 Jan 7. J Biol Chem. 2002. PMID: 11781316 Free article.

6

A statin-based inhibitor of lymphocyte function antigen-1 protects against ischemia/reperfusion-induced leukocyte adhesion in the colon.

Wan MX, Schramm R, Klintman D, Welzenbach K, Weitz-Schmidt G, Thorlacius H. Wan MX, et al. Br J Pharmacol. 2003 Sep;140(2):395-401. doi: 10.1038/sj.bjp.0705432. Epub 2003 Aug 26. Br J Pharmacol. 2003. PMID: 12970101 Free PMC article.

7

Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain.

Ullrich T, Baumann K, Welzenbach K, Schmutz S, Camenisch G, Meingassner JG, Weitz-Schmidt G. Ullrich T, et al. Bioorg Med Chem Lett. 2004 May 17;14(10):2483-7. doi: 10.1016/j.bmcl.2004.03.006. Bioorg Med Chem Lett. 2004. PMID: 15109637

8

Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo.

Weitz-Schmidt G, Welzenbach K, Dawson J, Kallen J. Weitz-Schmidt G, et al. J Biol Chem. 2004 Nov 5;279(45):46764-71. doi: 10.1074/jbc.M407951200. Epub 2004 Aug 10. J Biol Chem. 2004. PMID: 15304496 Free article.

9

Pharmacodynamics in the development of new immunosuppressive drugs.

Burkhart C, Heusser C, Morris RE, Raulf F, Weckbecker G, Weitz-Schmidt G, Welzenbach K. Burkhart C, et al. Ther Drug Monit. 2004 Dec;26(6):588-92. doi: 10.1097/00007691-200412000-00002. Ther Drug Monit. 2004. PMID: 15570181 Review.

10

1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.

Wattanasin S, Kallen J, Myers S, Guo Q, Sabio M, Ehrhardt C, Albert R, Hommel U, Weckbecker G, Welzenbach K, Weitz-Schmidt G. Wattanasin S, et al. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1217-20. doi: 10.1016/j.bmcl.2004.11.072. Bioorg Med Chem Lett. 2005. PMID: 15686945

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