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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S. Farris W, et al. Among authors: frosch mp. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4162-7. doi: 10.1073/pnas.0230450100. Epub 2003 Mar 12. Proc Natl Acad Sci U S A. 2003. PMID: 12634421 Free PMC article.
Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin.
Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Frosch MP, Ding K, Ito M, Kim TW, Tanzi RE, Oyama F, Tabira T, Ando S, Ihara Y. Sawamura N, et al. Among authors: frosch mp. J Biol Chem. 2000 Sep 8;275(36):27901-8. doi: 10.1074/jbc.M004308200. J Biol Chem. 2000. PMID: 10846187 Free article.
Presenilin-mediated modulation of capacitative calcium entry.
Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW. Yoo AS, et al. Among authors: frosch mp. Neuron. 2000 Sep;27(3):561-72. doi: 10.1016/s0896-6273(00)00066-0. Neuron. 2000. PMID: 11055438 Free article.
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS. Schlossmacher MG, et al. Among authors: frosch mp. Am J Pathol. 2002 May;160(5):1655-67. doi: 10.1016/S0002-9440(10)61113-3. Am J Pathol. 2002. PMID: 12000718 Free PMC article.
509 results