Knight WB - Search Results

1

Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines.

Gaul MD, Guo Y, Affleck K, Cockerill GS, Gilmer TM, Griffin RJ, Guntrip S, Keith BR, Knight WB, Mullin RJ, Murray DM, Rusnak DW, Smith K, Tadepalli S, Wood ER, Lackey K. Gaul MD, et al. Among authors: knight wb. Bioorg Med Chem Lett. 2003 Feb 24;13(4):637-40. doi: 10.1016/s0960-894x(02)01047-8. Bioorg Med Chem Lett. 2003. PMID: 12639547

2

The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer.

Rusnak DW, Affleck K, Cockerill SG, Stubberfield C, Harris R, Page M, Smith KJ, Guntrip SB, Carter MC, Shaw RJ, Jowett A, Stables J, Topley P, Wood ER, Brignola PS, Kadwell SH, Reep BR, Mullin RJ, Alligood KJ, Keith BR, Crosby RM, Murray DM, Knight WB, Gilmer TM, Lackey K. Rusnak DW, et al. Among authors: knight wb. Cancer Res. 2001 Oct 1;61(19):7196-203. Cancer Res. 2001. PMID: 11585755

3

The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.

Rusnak DW, Lackey K, Affleck K, Wood ER, Alligood KJ, Rhodes N, Keith BR, Murray DM, Knight WB, Mullin RJ, Gilmer TM. Rusnak DW, et al. Among authors: knight wb. Mol Cancer Ther. 2001 Dec;1(2):85-94. Mol Cancer Ther. 2001. PMID: 12467226

4

Comparison of the biochemical and kinetic properties of the type 1 receptor tyrosine kinase intracellular domains. Demonstration of differential sensitivity to kinase inhibitors.

Brignola PS, Lackey K, Kadwell SH, Hoffman C, Horne E, Carter HL, Stuart JD, Blackburn K, Moyer MB, Alligood KJ, Knight WB, Wood ER. Brignola PS, et al. Among authors: knight wb. J Biol Chem. 2002 Jan 11;277(2):1576-85. doi: 10.1074/jbc.M105907200. Epub 2001 Nov 5. J Biol Chem. 2002. PMID: 11696537 Free article.

5

Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines.

Tian G, Cory M, Smith AA, Knight WB. Tian G, et al. Among authors: knight wb. Biochemistry. 2001 Jun 19;40(24):7084-91. doi: 10.1021/bi0100586. Biochemistry. 2001. PMID: 11401553

6

Orally active beta-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution.

Hagmann WK, Kissinger AL, Shah SK, Finke PE, Dorn CP, Brause KA, Ashe BM, Weston H, Maycock AL, Knight WB, et al. Hagmann WK, et al. Among authors: knight wb. J Med Chem. 1993 Mar 19;36(6):771-7. doi: 10.1021/jm00058a015. J Med Chem. 1993. PMID: 8459404

7

Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins.

Shah SK, Brause KA, Chandler GO, Finke PE, Ashe BM, Weston H, Knight WB, Maycock AL, Doherty JB. Shah SK, et al. Among authors: knight wb. J Med Chem. 1990 Sep;33(9):2529-35. doi: 10.1021/jm00171a030. J Med Chem. 1990. PMID: 2391693

8

Exploration of the sequence specificity of pp60c-src tyrosine kinase. Minimal peptide sequence required for maximal activity.

Edison AM, Barker SC, Kassel DB, Luther MA, Knight WB. Edison AM, et al. Among authors: knight wb. J Biol Chem. 1995 Nov 10;270(45):27112-5. doi: 10.1074/jbc.270.45.27112. J Biol Chem. 1995. PMID: 7592964 Free article.

9

Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides.

Finke PE, Ashe BM, Knight WB, Maycock AL, Navia MA, Shah SK, Thompson KR, Underwood DJ, Weston H, Zimmerman M, et al. Finke PE, et al. Among authors: knight wb. J Med Chem. 1990 Sep;33(9):2522-8. doi: 10.1021/jm00171a029. J Med Chem. 1990. PMID: 2391692

10

Kinetic mechanisms of the forward and reverse pp60c-src tyrosine kinase reactions.

Boerner RJ, Barker SC, Knight WB. Boerner RJ, et al. Among authors: knight wb. Biochemistry. 1995 Dec 19;34(50):16419-23. doi: 10.1021/bi00050a024. Biochemistry. 1995. PMID: 8845369

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