Curtis NR - Search Results

1

Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists.

Curtis NR, Diggle HJ, Kulagowski JJ, London C, Grimwood S, Hutson PH, Murray F, Richards P, Macaulay A, Wafford KA. Curtis NR, et al. Bioorg Med Chem Lett. 2003 Feb 24;13(4):693-6. doi: 10.1016/s0960-894x(02)01060-0. Bioorg Med Chem Lett. 2003. PMID: 12639560

2

Orally efficacious NR2B-selective NMDA receptor antagonists.

Claiborne CF, McCauley JA, Libby BE, Curtis NR, Diggle HJ, Kulagowski JJ, Michelson SR, Anderson KD, Claremon DA, Freidinger RM, Bednar RA, Mosser SD, Gaul SL, Connolly TM, Condra CL, Bednar B, Stump GL, Lynch JJ, Macaulay A, Wafford KA, Koblan KS, Liverton NJ. Claiborne CF, et al. Among authors: curtis nr. Bioorg Med Chem Lett. 2003 Feb 24;13(4):697-700. doi: 10.1016/s0960-894x(02)01061-2. Bioorg Med Chem Lett. 2003. PMID: 12639561

3

Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands.

Thomson CG, Beer MS, Curtis NR, Diggle HJ, Handford E, Kulagowski JJ. Thomson CG, et al. Among authors: curtis nr. Bioorg Med Chem Lett. 2004 Feb 9;14(3):677-80. doi: 10.1016/j.bmcl.2003.11.050. Bioorg Med Chem Lett. 2004. PMID: 14741267

4

Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands.

Curtis NR, Kulagowski JJ, Leeson PD, Ridgill MP, Emms F, Freedman SB, Patel S, Patel S. Curtis NR, et al. Bioorg Med Chem Lett. 1999 Feb 22;9(4):585-8. doi: 10.1016/s0960-894x(99)00025-6. Bioorg Med Chem Lett. 1999. PMID: 10098669

5

3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor.

Kulagowski JJ, Baker R, Curtis NR, Leeson PD, Mawer IM, Moseley AM, Ridgill MP, Rowley M, Stansfield I, Foster AC, et al. Kulagowski JJ, et al. Among authors: curtis nr. J Med Chem. 1994 May 13;37(10):1402-5. doi: 10.1021/jm00036a002. J Med Chem. 1994. PMID: 8182696 No abstract available.

6

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

Kulagowski JJ, Broughton HB, Curtis NR, Mawer IM, Ridgill MP, Baker R, Emms F, Freedman SB, Marwood R, Patel S, Patel S, Ragan CI, Leeson PD. Kulagowski JJ, et al. Among authors: curtis nr. J Med Chem. 1996 May 10;39(10):1941-2. doi: 10.1021/jm9600712. J Med Chem. 1996. PMID: 8642550 No abstract available.

7

Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor.

Patel S, Patel S, Marwood R, Emms F, Marston D, Leeson PD, Curtis NR, Kulagowski JJ, Freedman SB. Patel S, et al. Among authors: curtis nr. Mol Pharmacol. 1996 Dec;50(6):1658-64. Mol Pharmacol. 1996. PMID: 8967990

8

Stereocontrolled syntheses of epimeric 3-aryl-6-phenyl-1-oxa-7-azaspiro(4.5)decane NK-1 receptor antagonist precursors.

Kulagowski JJ, Curtis NR, Swain CJ, Williams BJ. Kulagowski JJ, et al. Among authors: curtis nr. Org Lett. 2001 Mar 8;3(5):667-70. doi: 10.1021/ol006944a. Org Lett. 2001. PMID: 11259032

9

L-745,870, a subtype selective dopamine D4 receptor antagonist, does not exhibit a neuroleptic-like profile in rodent behavioral tests.

Bristow LJ, Collinson N, Cook GP, Curtis N, Freedman SB, Kulagowski JJ, Leeson PD, Patel S, Ragan CI, Ridgill M, Saywell KL, Tricklebank MD. Bristow LJ, et al. J Pharmacol Exp Ther. 1997 Dec;283(3):1256-63. J Pharmacol Exp Ther. 1997. PMID: 9400001

10

Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor.

Leeson PD, Baker R, Carling RW, Curtis NR, Moore KW, Williams BJ, Foster AC, Donald AE, Kemp JA, Marshall GR. Leeson PD, et al. Among authors: curtis nr. J Med Chem. 1991 Apr;34(4):1243-52. doi: 10.1021/jm00108a002. J Med Chem. 1991. PMID: 1826744

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