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The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.
Pluquet O, North S, Bhoumik A, Dimas K, Ronai Z, Hainaut P. Pluquet O, et al. Among authors: hainaut p. J Biol Chem. 2003 Apr 4;278(14):11879-87. doi: 10.1074/jbc.M207396200. Epub 2003 Jan 16. J Biol Chem. 2003. PMID: 12531896 Free article.
In a previous study (North, S., El-Ghissassi, F., Pluquet, O., Verhaegh, G., and Hainaut, P. (2000) Oncogene 19, 1206-1214), we have shown that WR1065 activates wild-type p53 in cultured cells. ...
In a previous study (North, S., El-Ghissassi, F., Pluquet, O., Verhaegh, G., and Hainaut, P. (2000) Oncogene 19, 1206-1214), w …
Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper.
Verhaegh GW, Richard MJ, Hainaut P. Verhaegh GW, et al. Among authors: hainaut p. Mol Cell Biol. 1997 Oct;17(10):5699-706. doi: 10.1128/MCB.17.10.5699. Mol Cell Biol. 1997. PMID: 9315628 Free PMC article.
We have previously reported that p53 protein binds copper in vitro in the form of Cu1+ (P. Hainaut, N. Rolley, M. Davies, and J. Milner, Oncogene 10:27-32, 1995). The data reported here indicate that intracellular levels and redox activity of copper are critical for …
We have previously reported that p53 protein binds copper in vitro in the form of Cu1+ (P. Hainaut, N. Rolley, M. Davies, and …
Genotoxic and non-genotoxic pathways of p53 induction.
Pluquet O, Hainaut P. Pluquet O, et al. Among authors: hainaut p. Cancer Lett. 2001 Dec 10;174(1):1-15. doi: 10.1016/s0304-3835(01)00698-x. Cancer Lett. 2001. PMID: 11675147 Review.
475 results