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Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.
Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM; Pharmacogenetics Of Membrane Transporters Investigators. Shu Y, et al. Among authors: leabman mk. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5902-7. doi: 10.1073/pnas.0730858100. Epub 2003 Apr 28. Proc Natl Acad Sci U S A. 2003. PMID: 12719534 Free PMC article.
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function.
Leabman MK, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Clark AG, Herskowitz I, Giacomini KM; Pharmacogenetics of Membrane Transporters Investigators. Leabman MK, et al. Pharmacogenetics. 2002 Jul;12(5):395-405. doi: 10.1097/00008571-200207000-00007. Pharmacogenetics. 2002. PMID: 12142729
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.
Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, Giacomini KM; Pharmacogenetics Of Membrane Transporters Investigators. Leabman MK, et al. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5896-901. doi: 10.1073/pnas.0730857100. Epub 2003 Apr 28. Proc Natl Acad Sci U S A. 2003. PMID: 12719533 Free PMC article.
Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).
Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM. Fujita T, et al. Among authors: leabman mk. Pharmacogenet Genomics. 2005 Apr;15(4):201-9. doi: 10.1097/01213011-200504000-00003. Pharmacogenet Genomics. 2005. PMID: 15864112
24 results