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Transforming growth factor-beta-Smad signaling pathway negatively regulates nontypeable Haemophilus influenzae-induced MUC5AC mucin transcription via mitogen-activated protein kinase (MAPK) phosphatase-1-dependent inhibition of p38 MAPK.
Jono H, Xu H, Kai H, Lim DJ, Kim YS, Feng XH, Li JD. Jono H, et al. Among authors: kai h. J Biol Chem. 2003 Jul 25;278(30):27811-9. doi: 10.1074/jbc.M301773200. Epub 2003 May 6. J Biol Chem. 2003. PMID: 12734193 Free article.
Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase.
Shuto T, Imasato A, Jono H, Sakai A, Xu H, Watanabe T, Rixter DD, Kai H, Andalibi A, Linthicum F, Guan YL, Han J, Cato AC, Lim DJ, Akira S, Li JD. Shuto T, et al. Among authors: kai h. J Biol Chem. 2002 May 10;277(19):17263-70. doi: 10.1074/jbc.M112190200. Epub 2002 Feb 26. J Biol Chem. 2002. PMID: 11867630 Free article.
The transforming growth factor-beta-Smad3/4 signaling pathway acts as a positive regulator for TLR2 induction by bacteria via a dual mechanism involving functional cooperation with NF-kappaB and MAPK phosphatase 1-dependent negative cross-talk with p38 MAPK.
Mikami F, Lim JH, Ishinaga H, Ha UH, Gu H, Koga T, Jono H, Kai H, Li JD. Mikami F, et al. Among authors: kai h. J Biol Chem. 2006 Aug 4;281(31):22397-22408. doi: 10.1074/jbc.M602124200. Epub 2006 Jun 5. J Biol Chem. 2006. PMID: 16754688 Free article.
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.
Lee J, Komatsu K, Lee BC, Lim JH, Jono H, Xu H, Kai H, Zhang ZJ, Yan C, Li JD. Lee J, et al. Among authors: kai h. J Biol Chem. 2012 Jun 29;287(27):22799-811. doi: 10.1074/jbc.M111.337378. Epub 2012 May 18. J Biol Chem. 2012. PMID: 22610099 Free PMC article.
Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells.
Shuto T, Xu H, Wang B, Han J, Kai H, Gu XX, Murphy TF, Lim DJ, Li JD. Shuto T, et al. Among authors: kai h. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8774-9. doi: 10.1073/pnas.151236098. Epub 2001 Jul 3. Proc Natl Acad Sci U S A. 2001. PMID: 11438700 Free PMC article.
704 results