End DW - Search Results

1

Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777.

Gunning WT, Kramer PM, Lubet RA, Steele VE, End DW, Wouters W, Pereira MA. Gunning WT, et al. Among authors: end dw. Clin Cancer Res. 2003 May;9(5):1927-30. Clin Cancer Res. 2003. PMID: 12738751

2

Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.

End DW, Smets G, Todd AV, Applegate TL, Fuery CJ, Angibaud P, Venet M, Sanz G, Poignet H, Skrzat S, Devine A, Wouters W, Bowden C. End DW, et al. Cancer Res. 2001 Jan 1;61(1):131-7. Cancer Res. 2001. PMID: 11196150

3

Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations.

Lubet RA, Christov K, You M, Yao R, Steele VE, End DW, Juliana MM, Grubbs CJ. Lubet RA, et al. Among authors: end dw. Mol Cancer Ther. 2006 Apr;5(4):1073-8. doi: 10.1158/1535-7163.MCT-05-0398. Mol Cancer Ther. 2006. PMID: 16648579

4

Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets.

Yao R, Wang Y, Lu Y, Lemon WJ, End DW, Grubbs CJ, Lubet RA, You M. Yao R, et al. Among authors: end dw. Carcinogenesis. 2006 Jul;27(7):1420-31. doi: 10.1093/carcin/bgi341. Epub 2006 Jan 10. Carcinogenesis. 2006. PMID: 16403772

5

5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.

Angibaud P, Bourdrez X, Devine A, End DW, Freyne E, Ligny Y, Muller P, Mannens G, Pilatte I, Poncelet V, Skrzat S, Smets G, Van Dun J, Van Remoortere P, Venet M, Wouters W. Angibaud P, et al. Among authors: end dw. Bioorg Med Chem Lett. 2003 May 5;13(9):1543-7. doi: 10.1016/s0960-894x(03)00180-x. Bioorg Med Chem Lett. 2003. PMID: 12699751

6

4-methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA.

Angibaud P, Saha AK, Bourdrez X, End DW, Freyne E, Lezouret P, Mannens G, Mevellec L, Meyer C, Pilatte I, Poncelet V, Roux B, Smets G, Van Dun J, Venet M, Wouters W. Angibaud P, et al. Among authors: end dw. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4361-4. doi: 10.1016/j.bmcl.2003.09.043. Bioorg Med Chem Lett. 2003. PMID: 14643326

7

Impact on farnesyltransferase inhibition of 4-chlorophenyl moiety replacement in the Zarnestra series.

Angibaud P, Mevellec L, Meyer C, Bourdrez X, Lezouret P, Pilatte I, Poncelet V, Roux B, Merillon S, End DW, Van Dun J, Wouters W, Venet M. Angibaud P, et al. Among authors: end dw. Eur J Med Chem. 2007 May;42(5):702-14. doi: 10.1016/j.ejmech.2006.12.007. Epub 2007 Jan 9. Eur J Med Chem. 2007. PMID: 17316920

8

The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft.

Delmas C, End D, Rochaix P, Favre G, Toulas C, Cohen-Jonathan E. Delmas C, et al. Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):6062-8. Clin Cancer Res. 2003. PMID: 14676133

9

Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.

Angibaud P, Bourdrez X, End DW, Freyne E, Janicot M, Lezouret P, Ligny Y, Mannens G, Damsch S, Mevellec L, Meyer C, Muller P, Pilatte I, Poncelet V, Roux B, Smets G, Van Dun J, Van Remoortere P, Venet M, Wouters W. Angibaud P, et al. Among authors: end dw. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4365-9. doi: 10.1016/j.bmcl.2003.08.080. Bioorg Med Chem Lett. 2003. PMID: 14643327

10

Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.

Kelland LR, Smith V, Valenti M, Patterson L, Clarke PA, Detre S, End D, Howes AJ, Dowsett M, Workman P, Johnston SR. Kelland LR, et al. Clin Cancer Res. 2001 Nov;7(11):3544-50. Clin Cancer Res. 2001. PMID: 11705875

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