Selkoe DJ - Search Results

1

Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.

Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Kimberly WT, et al. Among authors: selkoe dj. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6382-7. doi: 10.1073/pnas.1037392100. Epub 2003 May 9. Proc Natl Acad Sci U S A. 2003. PMID: 12740439 Free PMC article.

2

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.

Hung AY, Koo EH, Haass C, Selkoe DJ. Hung AY, et al. Among authors: selkoe dj. Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9439-43. doi: 10.1073/pnas.89.20.9439. Proc Natl Acad Sci U S A. 1992. PMID: 1409654 Free PMC article.

3

Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels.

Tamaoka A, Kalaria RN, Lieberburg I, Selkoe DJ. Tamaoka A, et al. Among authors: selkoe dj. Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1345-9. doi: 10.1073/pnas.89.4.1345. Proc Natl Acad Sci U S A. 1992. PMID: 1531538 Free PMC article.

4

Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes.

Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ. Schlossmacher MG, et al. Among authors: selkoe dj. Neurobiol Aging. 1992 May-Jun;13(3):421-34. doi: 10.1016/0197-4580(92)90117-g. Neurobiol Aging. 1992. PMID: 1625772

5

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

Selkoe DJ, Podlisny MB, Joachim CL, Vickers EA, Lee G, Fritz LC, Oltersdorf T. Selkoe DJ, et al. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7341-5. doi: 10.1073/pnas.85.19.7341. Proc Natl Acad Sci U S A. 1988. PMID: 3140239 Free PMC article.

6

Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.

Kirschner DA, Inouye H, Duffy LK, Sinclair A, Lind M, Selkoe DJ. Kirschner DA, et al. Among authors: selkoe dj. Proc Natl Acad Sci U S A. 1987 Oct;84(19):6953-7. doi: 10.1073/pnas.84.19.6953. Proc Natl Acad Sci U S A. 1987. PMID: 3477820 Free PMC article.

7

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.

Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. Haass C, et al. Among authors: selkoe dj. Nat Med. 1995 Dec;1(12):1291-6. doi: 10.1038/nm1295-1291. Nat Med. 1995. PMID: 7489411

8

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture.

Podlisny MB, Ostaszewski BL, Squazzo SL, Koo EH, Rydell RE, Teplow DB, Selkoe DJ. Podlisny MB, et al. Among authors: selkoe dj. J Biol Chem. 1995 Apr 21;270(16):9564-70. doi: 10.1074/jbc.270.16.9564. J Biol Chem. 1995. PMID: 7721886 Free article.

9

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.

Citron M, Vigo-Pelfrey C, Teplow DB, Miller C, Schenk D, Johnston J, Winblad B, Venizelos N, Lannfelt L, Selkoe DJ. Citron M, et al. Among authors: selkoe dj. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11993-7. doi: 10.1073/pnas.91.25.11993. Proc Natl Acad Sci U S A. 1994. PMID: 7991571 Free PMC article.

10

Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.

Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS. Greenberg SM, et al. Among authors: selkoe dj. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7104-8. doi: 10.1073/pnas.91.15.7104. Proc Natl Acad Sci U S A. 1994. PMID: 8041753 Free PMC article.

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