Siegfried G - Search Results

1

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.

Siegfried G, Basak A, Cromlish JA, Benjannet S, Marcinkiewicz J, Chrétien M, Seidah NG, Khatib AM. Siegfried G, et al. J Clin Invest. 2003 Jun;111(11):1723-32. doi: 10.1172/JCI17220. J Clin Invest. 2003. PMID: 12782675 Free PMC article.

2

The mechanism of inhibition of DNA synthesis in articular chondrocytes from young and old rats by nitric oxide.

Khatib AM, Siegfried G, Quintero M, Mitrovic DR. Khatib AM, et al. Among authors: siegfried g. Nitric Oxide. 1997 Jun;1(3):218-25. doi: 10.1006/niox.1997.0126. Nitric Oxide. 1997. PMID: 9704583

3

Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions.

Khatib AM, Siegfried G, Prat A, Luis J, Chrétien M, Metrakos P, Seidah NG. Khatib AM, et al. Among authors: siegfried g. J Biol Chem. 2001 Aug 17;276(33):30686-93. doi: 10.1074/jbc.M101725200. Epub 2001 Jun 11. J Biol Chem. 2001. PMID: 11402025 Free article.

4

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy.

Khatib AM, Siegfried G, Chrétien M, Metrakos P, Seidah NG. Khatib AM, et al. Among authors: siegfried g. Am J Pathol. 2002 Jun;160(6):1921-35. doi: 10.1016/S0002-9440(10)61140-6. Am J Pathol. 2002. PMID: 12057895 Free PMC article. Review.

5

The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

Siegfried G, Khatib AM, Benjannet S, Chrétien M, Seidah NG. Siegfried G, et al. Cancer Res. 2003 Apr 1;63(7):1458-63. Cancer Res. 2003. PMID: 12670890

6

Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases.

Siegfried G, Basak A, Prichett-Pejic W, Scamuffa N, Ma L, Benjannet S, Veinot JP, Calvo F, Seidah N, Khatib AM. Siegfried G, et al. Oncogene. 2005 Oct 20;24(46):6925-35. doi: 10.1038/sj.onc.1208838. Oncogene. 2005. PMID: 16007151

7

Endo/exo-proteolysis in neoplastic progression and metastasis.

Khatib AM, Bassi D, Siegfried G, Klein-Szanto AJ, Ouafik L. Khatib AM, et al. Among authors: siegfried g. J Mol Med (Berl). 2005 Nov;83(11):856-64. doi: 10.1007/s00109-005-0692-y. Epub 2005 Aug 26. J Mol Med (Berl). 2005. PMID: 16133424 Review.

8

Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.

Lapierre M, Siegfried G, Scamuffa N, Bontemps Y, Calvo F, Seidah NG, Khatib AM. Lapierre M, et al. Among authors: siegfried g. Cancer Res. 2007 Oct 1;67(19):9030-4. doi: 10.1158/0008-5472.CAN-07-0807. Cancer Res. 2007. PMID: 17909005

9

Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.

Scamuffa N, Siegfried G, Bontemps Y, Ma L, Basak A, Cherel G, Calvo F, Seidah NG, Khatib AM. Scamuffa N, et al. Among authors: siegfried g. J Clin Invest. 2008 Jan;118(1):352-63. doi: 10.1172/JCI32040. J Clin Invest. 2008. PMID: 18064302 Free PMC article.

10

Inhibitory feature of the proprotein convertases prosegments.

Bontemps Y, Lapierre M, Siegfried G, Calvo F, Khatib AM. Bontemps Y, et al. Among authors: siegfried g. Med Chem. 2008 Mar;4(2):116-20. doi: 10.2174/157340608783789176. Med Chem. 2008. PMID: 18336330

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