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HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo.
Fischbach NA, Rozenfeld S, Shen W, Fong S, Chrobak D, Ginzinger D, Kogan SC, Radhakrishnan A, Le Beau MM, Largman C, Lawrence HJ. Fischbach NA, et al. Among authors: le beau mm. Blood. 2005 Feb 15;105(4):1456-66. doi: 10.1182/blood-2004-04-1583. Epub 2004 Nov 2. Blood. 2005. PMID: 15522959 Free article.
Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia.
Jones L, Wei G, Sevcikova S, Phan V, Jain S, Shieh A, Wong JC, Li M, Dubansky J, Maunakea ML, Ochoa R, Zhu G, Tennant TR, Shannon KM, Lowe SW, Le Beau MM, Kogan SC. Jones L, et al. Among authors: le beau mm. J Exp Med. 2010 Nov 22;207(12):2581-94. doi: 10.1084/jem.20091071. Epub 2010 Nov 8. J Exp Med. 2010. PMID: 21059853 Free PMC article.
PML-RARα co-operates with Sox4 in acute myeloid leukemia development in mice.
Omidvar N, Maunakea ML, Jones L, Sevcikova S, Yin B, Himmel KL, Tennant TR, Le Beau MM, Largaespada DA, Kogan SC. Omidvar N, et al. Among authors: le beau mm. Haematologica. 2013 Mar;98(3):424-7. doi: 10.3324/haematol.2011.057067. Epub 2012 Nov 9. Haematologica. 2013. PMID: 23144197 Free PMC article.
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SW. Zhao Z, et al. Among authors: le beau mm. Nat Genet. 2015 May;47(5):539-43. doi: 10.1038/ng.3251. Epub 2015 Mar 30. Nat Genet. 2015. PMID: 25822087 Free PMC article.
483 results