Nadin A - Search Results

1

Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.

Lewis HD, Pérez Revuelta BI, Nadin A, Neduvelil JG, Harrison T, Pollack SJ, Shearman MS. Lewis HD, et al. Among authors: nadin a. Biochemistry. 2003 Jun 24;42(24):7580-6. doi: 10.1021/bi034310g. Biochemistry. 2003. PMID: 12809514

2

Synthesis and gamma-secretase activity of APP substrate-based hydroxyethylene dipeptide isosteres.

Nadin A, Owens AP, Castro JL, Harrison T, Shearman MS. Nadin A, et al. Bioorg Med Chem Lett. 2003 Jan 6;13(1):37-41. doi: 10.1016/s0960-894x(02)00840-5. Bioorg Med Chem Lett. 2003. PMID: 12467612

3

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

Beher D, Fricker M, Nadin A, Clarke EE, Wrigley JD, Li YM, Culvenor JG, Masters CL, Harrison T, Shearman MS. Beher D, et al. Among authors: nadin a. Biochemistry. 2003 Jul 15;42(27):8133-42. doi: 10.1021/bi034045z. Biochemistry. 2003. PMID: 12846562

4

High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitors.

Owens AP, Nadin A, Talbot AC, Clarke EE, Harrison T, Lewis HD, Reilly M, Wrigley JD, Castro JL. Owens AP, et al. Among authors: nadin a. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4143-5. doi: 10.1016/j.bmcl.2003.07.031. Bioorg Med Chem Lett. 2003. PMID: 14592525

5

Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.

Wrigley JD, Nunn EJ, Nyabi O, Clarke EE, Hunt P, Nadin A, De Strooper B, Shearman MS, Beher D. Wrigley JD, et al. Among authors: nadin a. J Neurochem. 2004 Sep;90(6):1312-20. doi: 10.1111/j.1471-4159.2004.02596.x. J Neurochem. 2004. PMID: 15341515 Free article.

6

Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide].

Best JD, Jay MT, Otu F, Ma J, Nadin A, Ellis S, Lewis HD, Pattison C, Reilly M, Harrison T, Shearman MS, Williamson TL, Atack JR. Best JD, et al. Among authors: nadin a. J Pharmacol Exp Ther. 2005 May;313(2):902-8. doi: 10.1124/jpet.104.081174. Epub 2005 Mar 2. J Pharmacol Exp Ther. 2005. PMID: 15743924

7

3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.

Shaw D, Best J, Dinnell K, Nadin A, Shearman M, Pattison C, Peachey J, Reilly M, Williams B, Wrigley J, Harrison T. Shaw D, et al. Among authors: nadin a. Bioorg Med Chem Lett. 2006 Jun 1;16(11):3073-7. doi: 10.1016/j.bmcl.2005.12.083. Epub 2006 Apr 17. Bioorg Med Chem Lett. 2006. PMID: 16617016

8

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.

Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ. Li YM, et al. Among authors: nadin a. Nature. 2000 Jun 8;405(6787):689-94. doi: 10.1038/35015085. Nature. 2000. PMID: 10864326

9

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity.

Shearman MS, Beher D, Clarke EE, Lewis HD, Harrison T, Hunt P, Nadin A, Smith AL, Stevenson G, Castro JL. Shearman MS, et al. Among authors: nadin a. Biochemistry. 2000 Aug 1;39(30):8698-704. doi: 10.1021/bi0005456. Biochemistry. 2000. PMID: 10913280

10

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.

Beher D, Wrigley JD, Nadin A, Evin G, Masters CL, Harrison T, Castro JL, Shearman MS. Beher D, et al. Among authors: nadin a. J Biol Chem. 2001 Nov 30;276(48):45394-402. doi: 10.1074/jbc.M103075200. Epub 2001 Sep 26. J Biol Chem. 2001. PMID: 11574530 Free article.

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