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Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanol.
Neelamkavil S, Arison B, Birzin E, Feng JJ, Chen KH, Lin A, Cheng FC, Taylor L, Thornton ER, Smith AB 3rd, Hirschmann R. Neelamkavil S, et al. J Med Chem. 2005 Jun 16;48(12):4025-30. doi: 10.1021/jm058184l. J Med Chem. 2005. PMID: 15943475
Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile.
Balani SK, Xu X, Pratha V, Koss MA, Amin RD, Dufresne C, Miller RR, Arison BH, Doss GA, Chiba M, Freeman A, Holland SD, Schwartz JI, Lasseter KC, Gertz BJ, Isenberg JI, Rogers JD, Lin JH, Baillie TA. Balani SK, et al. Among authors: arison bh. Drug Metab Dispos. 1997 Nov;25(11):1282-7. Drug Metab Dispos. 1997. PMID: 9351905 Clinical Trial.
Metabolism of rofecoxib in vitro using human liver subcellular fractions.
Slaughter D, Takenaga N, Lu P, Assang C, Walsh DJ, Arison BH, Cui D, Halpin RA, Geer LA, Vyas KP, Baillie TA. Slaughter D, et al. Among authors: arison bh. Drug Metab Dispos. 2003 Nov;31(11):1398-408. doi: 10.1124/dmd.31.11.1398. Drug Metab Dispos. 2003. PMID: 14570773
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