Peach ML - Search Results

1

Structural basis for a non-phosphorus-containing cyclic peptide binding to Grb2-SH2 domain with high affinity.

Li P, Zhang M, Peach ML, Zhang X, Liu H, Nicklaus M, Yang D, Roller PP. Li P, et al. Among authors: peach ml. Biochem Biophys Res Commun. 2003 Aug 8;307(4):1038-44. doi: 10.1016/s0006-291x(03)01291-9. Biochem Biophys Res Commun. 2003. PMID: 12878216

2

Structure-based design of thioether-bridged cyclic phosphopeptides binding to Grb2-SH2 domain.

Li P, Peach ML, Zhang M, Liu H, Yang D, Nicklaus M, Roller PP. Li P, et al. Among authors: peach ml. Bioorg Med Chem Lett. 2003 Mar 10;13(5):895-9. doi: 10.1016/s0960-894x(03)00015-5. Bioorg Med Chem Lett. 2003. PMID: 12617916

3

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

Sigano DM, Peach ML, Nacro K, Choi Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Sigano DM, et al. Among authors: peach ml. J Med Chem. 2003 Apr 24;46(9):1571-9. doi: 10.1021/jm020476o. J Med Chem. 2003. PMID: 12699375

4

Potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.

Li P, Zhang M, Long YQ, Peach ML, Liu H, Yang D, Nicklaus M, Roller PP. Li P, et al. Among authors: peach ml. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2173-7. doi: 10.1016/s0960-894x(03)00385-8. Bioorg Med Chem Lett. 2003. PMID: 12798329

5

Concise and enantioselective synthesis of Fmoc-Pmp(But)2-OH and design of potent Pmp-containing Grb2-SH2 domain antagonists.

Li P, Zhang M, Peach ML, Liu H, Yang D, Roller PP. Li P, et al. Among authors: peach ml. Org Lett. 2003 Aug 21;5(17):3095-8. doi: 10.1021/ol035078+. Org Lett. 2003. PMID: 12916990

6

Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C).

Tamamura H, Sigano DM, Lewin NE, Peach ML, Nicklaus MC, Blumberg PM, Marquez VE. Tamamura H, et al. Among authors: peach ml. J Med Chem. 2004 Sep 23;47(20):4858-64. doi: 10.1021/jm049723+. J Med Chem. 2004. PMID: 15369389

7

Small nonphosphorylated Grb2-SH2 domain antagonists evaluated by surface plasmon resonance technology.

Lung FD, Chang CW, Chong MC, Liou CC, Li P, Peach ML, Nicklaus MC, Lou BS, Roller PP. Lung FD, et al. Among authors: peach ml. Biopolymers. 2005;80(5):628-35. doi: 10.1002/bip.20209. Biopolymers. 2005. PMID: 15660381

8

Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.

Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: peach ml. J Med Chem. 2005 Sep 8;48(18):5738-48. doi: 10.1021/jm050352m. J Med Chem. 2005. PMID: 16134942 Free PMC article.

9

Evidence that sequence homologous region in LRAT-like proteins possesses anti-proliferative activity and DNA binding properties: translational implications and mechanism of action.

Simmons DP, Peach ML, Friedman JR, Green MM, Nicklaus MC, De Luca LM. Simmons DP, et al. Among authors: peach ml. Carcinogenesis. 2006 Apr;27(4):693-707. doi: 10.1093/carcin/bgi235. Epub 2005 Oct 18. Carcinogenesis. 2006. PMID: 16234259

10

Discovery of a novel nonphosphorylated pentapeptide motif displaying high affinity for Grb2-SH2 domain by the utilization of 3'-substituted tyrosine derivatives.

Song YL, Peach ML, Roller PP, Qiu S, Wang S, Long YQ. Song YL, et al. Among authors: peach ml. J Med Chem. 2006 Mar 9;49(5):1585-96. doi: 10.1021/jm050910x. J Med Chem. 2006. PMID: 16509576

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