Ward SA - Search Results

1

Heme binding contributes to antimalarial activity of bis-quaternary ammoniums.

Biagini GA, Richier E, Bray PG, Calas M, Vial H, Ward SA. Biagini GA, et al. Among authors: ward sa. Antimicrob Agents Chemother. 2003 Aug;47(8):2584-9. doi: 10.1128/AAC.47.8.2584-2589.2003. Antimicrob Agents Chemother. 2003. PMID: 12878523 Free PMC article.

2

Potent antihematozoan activity of novel bisthiazolium drug T16: evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp.

Richier E, Biagini GA, Wein S, Boudou F, Bray PG, Ward SA, Precigout E, Calas M, Dubremetz JF, Vial HJ. Richier E, et al. Among authors: ward sa. Antimicrob Agents Chemother. 2006 Oct;50(10):3381-8. doi: 10.1128/AAC.00443-06. Antimicrob Agents Chemother. 2006. PMID: 17005821 Free PMC article.

3

Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs.

Biagini GA, Pasini EM, Hughes R, De Koning HP, Vial HJ, O'Neill PM, Ward SA, Bray PG. Biagini GA, et al. Among authors: ward sa. Blood. 2004 Nov 15;104(10):3372-7. doi: 10.1182/blood-2004-03-1084. Epub 2004 Jun 17. Blood. 2004. PMID: 15205262 Free article.

4

Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria.

Biagini GA, Viriyavejakul P, O'neill PM, Bray PG, Ward SA. Biagini GA, et al. Among authors: ward sa. Antimicrob Agents Chemother. 2006 May;50(5):1841-51. doi: 10.1128/AAC.50.5.1841-1851.2006. Antimicrob Agents Chemother. 2006. PMID: 16641458 Free PMC article.

5

Drug-regulated expression of Plasmodium falciparum P-glycoprotein homologue 1: a putative role for nuclear receptors.

Johnson DJ, Owen A, Plant N, Bray PG, Ward SA. Johnson DJ, et al. Among authors: ward sa. Antimicrob Agents Chemother. 2008 Apr;52(4):1438-45. doi: 10.1128/AAC.01392-07. Epub 2008 Jan 14. Antimicrob Agents Chemother. 2008. PMID: 18195056 Free PMC article.

6

Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component.

Hawley SR, Bray PG, O'Neill PM, Naisbitt DJ, Park BK, Ward SA. Hawley SR, et al. Among authors: ward sa. Antimicrob Agents Chemother. 1996 Oct;40(10):2345-9. doi: 10.1128/AAC.40.10.2345. Antimicrob Agents Chemother. 1996. PMID: 8891142 Free PMC article.

7

Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro.

Hawley SR, Bray PG, Mungthin M, Atkinson JD, O'Neill PM, Ward SA. Hawley SR, et al. Among authors: ward sa. Antimicrob Agents Chemother. 1998 Mar;42(3):682-6. doi: 10.1128/AAC.42.3.682. Antimicrob Agents Chemother. 1998. PMID: 9517951 Free PMC article.

8

Altered binding of chloroquine to ferriprotoporphyrin IX is the basis for chloroquine resistance.

Raynes KJ, Bray PG, Ward SA. Raynes KJ, et al. Among authors: ward sa. Drug Resist Updat. 1999 Apr;2(2):97-103. doi: 10.1054/drup.1999.0077. Drug Resist Updat. 1999. PMID: 11504477

9

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.

Hindley S, Ward SA, Storr RC, Searle NL, Bray PG, Park BK, Davies J, O'Neill PM. Hindley S, et al. Among authors: ward sa. J Med Chem. 2002 Feb 28;45(5):1052-63. doi: 10.1021/jm0109816. J Med Chem. 2002. PMID: 11855985

10

Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.

Stocks PA, Raynes KJ, Bray PG, Park BK, O'Neill PM, Ward SA. Stocks PA, et al. Among authors: ward sa. J Med Chem. 2002 Nov 7;45(23):4975-83. doi: 10.1021/jm0108707. J Med Chem. 2002. PMID: 12408708

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