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Differential modulation of adhesion molecule expression by hydroxycarbamide in human endothelial cells from the micro- and macrocirculation: potential implications in sickle cell disease vasoocclusive events.
Laurance S, Lansiaux P, Pellay FX, Hauchecorne M, Benecke A, Elion J, Lapoumeroulie C. Laurance S, et al. Among authors: lapoumeroulie c. Haematologica. 2011 Apr;96(4):534-42. doi: 10.3324/haematol.2010.026740. Epub 2011 Jan 12. Haematologica. 2011. PMID: 21228039 Free PMC article.
Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/basal cell adhesion molecule (Lu/BCAM) through phosphodiesterase 4A activation.
Chaar V, Laurance S, Lapoumeroulie C, Cochet S, De Grandis M, Colin Y, Elion J, Le Van Kim C, El Nemer W. Chaar V, et al. Among authors: lapoumeroulie c. J Biol Chem. 2014 Apr 18;289(16):11512-11521. doi: 10.1074/jbc.M113.506121. Epub 2014 Mar 10. J Biol Chem. 2014. PMID: 24616094 Free PMC article.
68 results