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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides.
Chan L, Das SK, Reddy TJ, Poisson C, Proulx M, Pereira O, Courchesne M, Roy C, Wang W, Siddiqui A, Yannopoulos CG, Nguyen-Ba N, Labrecque D, Bethell R, Hamel M, Courtemanche-Asselin P, L'Heureux L, David M, Nicolas O, Brunette S, Bilimoria D, Bédard J. Chan L, et al. Among authors: proulx m. Bioorg Med Chem Lett. 2004 Feb 9;14(3):793-6. doi: 10.1016/j.bmcl.2003.10.067. Bioorg Med Chem Lett. 2004. PMID: 14741291
Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides.
Chan L, Pereira O, Reddy TJ, Das SK, Poisson C, Courchesne M, Proulx M, Siddiqui A, Yannopoulos CG, Nguyen-Ba N, Roy C, Nasturica D, Moinet C, Bethell R, Hamel M, L'Heureux L, David M, Nicolas O, Courtemanche-Asselin P, Brunette S, Bilimoria D, Bédard J. Chan L, et al. Among authors: proulx m. Bioorg Med Chem Lett. 2004 Feb 9;14(3):797-800. doi: 10.1016/j.bmcl.2003.10.068. Bioorg Med Chem Lett. 2004. PMID: 14741292
HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY.
Yannopoulos CG, Xu P, Ni F, Chan L, Pereira OZ, Reddy TJ, Das SK, Poisson C, Nguyen-Ba N, Turcotte N, Proulx M, Halab L, Wang W, Bédard J, Morin N, Hamel M, Nicolas O, Bilimoria D, L'Heureux L, Bethell R, Dionne G. Yannopoulos CG, et al. Among authors: proulx m. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5333-7. doi: 10.1016/j.bmcl.2004.08.018. Bioorg Med Chem Lett. 2004. PMID: 15454222
Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance.
Zhang B, Orning P, Lehman JW, Dinis A, Torres-Ulloa L, Elling R, Kelliher MA, Bertin J, Proulx MK, Ryan L, Kandasamy R, Espevik T, Pai AA, Fitzgerald KA, Lien E. Zhang B, et al. Among authors: proulx mk. bioRxiv [Preprint]. 2024 Nov 29:2024.11.27.625707. doi: 10.1101/2024.11.27.625707. bioRxiv. 2024. PMID: 39651143 Free PMC article. Preprint.
Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction.
Grace PS, Peters JM, Sixsmith J, Lu R, Luedeman C, Fenderson BA, Vickers A, Slein MD, Irvine EB, McKitrick T, Wei MH, Cummings RD, Wallace A, Cavacini LA, Choudhary A, Proulx MK, Sundling C, Källenius G, Reljic R, Ernst JD, Casadevall A, Locht C, Pinter A, Sasseti CM, Bryson BD, Fortune SM, Alter G. Grace PS, et al. Among authors: proulx mk. bioRxiv [Preprint]. 2024 Oct 11:2024.10.07.617070. doi: 10.1101/2024.10.07.617070. bioRxiv. 2024. PMID: 39416184 Free PMC article. Preprint.
194 results