de Costa BR - Search Results

1

Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinan.

de Costa BR, Iadarola MJ, Rothman RB, Berman KF, George C, Newman AH, Mahboubi A, Jacobson AE, Rice KC. de Costa BR, et al. J Med Chem. 1992 Jul 24;35(15):2826-35. doi: 10.1021/jm00093a016. J Med Chem. 1992. PMID: 1322988

2

Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogues.

Thurkauf A, de Costa B, Yamaguchi S, Mattson MV, Jacobson AE, Rice KC, Rogawski MA. Thurkauf A, et al. J Med Chem. 1990 May;33(5):1452-8. doi: 10.1021/jm00167a027. J Med Chem. 1990. PMID: 2329567

3

Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines.

Thurkauf A, de Costa B, Mattson MV, France CP, Price MT, Olney JW, Woods JH, Jacobson AE, Rice KC. Thurkauf A, et al. J Med Chem. 1990 Aug;33(8):2211-5. doi: 10.1021/jm00170a027. J Med Chem. 1990. PMID: 2374147

4

Synthesis, configuration, and activity of isomeric 2-phenyl-2-(N-piperidinyl)bicyclo[3.1.0]hexanes at phencyclidine and sigma binding sites.

de Costa BR, Mattson MV, George C, Linders JT. de Costa BR, et al. J Med Chem. 1992 Dec 11;35(25):4704-12. doi: 10.1021/jm00103a008. J Med Chem. 1992. PMID: 1469699

5

Novel site-directed affinity ligands for GABA-gated chloride channels: synthesis, characterization, and molecular modeling of 1-(isothiocyanatophenyl)-4-tert-butyl-2,6,7-trioxabicyclo[2.2.2]octanes.

de Costa BR, Lewin AH, Rice KC, Skolnick P, Schoenheimer JA. de Costa BR, et al. J Med Chem. 1991 May;34(5):1531-8. doi: 10.1021/jm00109a002. J Med Chem. 1991. PMID: 2033577

6

Probes for narcotic receptor mediated phenomena. 17. Synthesis and evaluation of a series of trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacet amide (U50,488) related isothiocyanate derivatives as opioid receptor affinity ligands.

de Costa BR, Rothman RB, Bykov V, Band L, Pert A, Jacobson AE, Rice KC. de Costa BR, et al. J Med Chem. 1990 Apr;33(4):1171-6. doi: 10.1021/jm00166a014. J Med Chem. 1990. PMID: 2157008

7

Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes.

de Costa BR, Rice KC, Bowen WD, Thurkauf A, Rothman RB, Band L, Jacobson AE, Radesca L, Contreras PC, Gray NM, et al. de Costa BR, et al. J Med Chem. 1990 Nov;33(11):3100-10. doi: 10.1021/jm00173a030. J Med Chem. 1990. PMID: 2172538

8

Selective and enantiospecific acylation of kappa opioid receptors by (1S,2S)-trans-2-isothiocyanato-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexy l] benzeneacetamide. Demonstration of kappa receptor heterogeneity.

de Costa BR, Rothman RB, Bykov V, Jacobson AE, Rice KC. de Costa BR, et al. J Med Chem. 1989 Feb;32(2):281-3. doi: 10.1021/jm00122a001. J Med Chem. 1989. PMID: 2536435 No abstract available.

9

Synthesis of an affinity ligand ('UPHIT') for in vivo acylation of the kappa-opioid receptor.

de Costa BR, Band L, Rothman RB, Jacobson AE, Bykov V, Pert A, Rice KC. de Costa BR, et al. FEBS Lett. 1989 Jun 5;249(2):178-82. doi: 10.1016/0014-5793(89)80619-2. FEBS Lett. 1989. PMID: 2544446 Free article.

10

Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands.

de Costa BR, Bowen WD, Hellewell SB, George C, Rothman RB, Reid AA, Walker JM, Jacobson AE, Rice KC. de Costa BR, et al. J Med Chem. 1989 Aug;32(8):1996-2002. doi: 10.1021/jm00128a050. J Med Chem. 1989. PMID: 2547074

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