Briggs SL - Search Results

1

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions.

Leduc AM, Trent JO, Wittliff JL, Bramlett KS, Briggs SL, Chirgadze NY, Wang Y, Burris TP, Spatola AF. Leduc AM, et al. Among authors: briggs sl. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11273-8. doi: 10.1073/pnas.1934759100. Epub 2003 Sep 17. Proc Natl Acad Sci U S A. 2003. PMID: 13679575 Free PMC article.

2

A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta.

Wang Y, Chirgadze NY, Briggs SL, Khan S, Jensen EV, Burris TP. Wang Y, et al. Among authors: briggs sl. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9908-11. doi: 10.1073/pnas.0510596103. Epub 2006 Jun 16. Proc Natl Acad Sci U S A. 2006. PMID: 16782818 Free PMC article.

3

Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.

Jin L, Briggs SL, Chandrasekhar S, Chirgadze NY, Clawson DK, Schevitz RW, Smiley DL, Tashjian AH, Zhang F. Jin L, et al. Among authors: briggs sl. J Biol Chem. 2000 Sep 1;275(35):27238-44. doi: 10.1074/jbc.M001134200. J Biol Chem. 2000. PMID: 10837469 Free article.

4

The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors.

Chirgadze NY, Sall DJ, Briggs SL, Clawson DK, Zhang M, Smith GF, Schevitz RW. Chirgadze NY, et al. Among authors: briggs sl. Protein Sci. 2000 Jan;9(1):29-36. doi: 10.1110/ps.9.1.29. Protein Sci. 2000. PMID: 10739244 Free PMC article.

5

Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis.

Chirgadze NY, Briggs SL, McAllister KA, Fischl AS, Zhao G. Chirgadze NY, et al. Among authors: briggs sl. EMBO J. 2000 Oct 16;19(20):5281-7. doi: 10.1093/emboj/19.20.5281. EMBO J. 2000. PMID: 11032795 Free PMC article.

6

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S2) binding site.

Sall DJ, Briggs SL, Chirgadze NY, Clawson DK, Gifford-Moore DS, Klimkowski VJ, McCowan JR, Smith GF, Wikel JH. Sall DJ, et al. Among authors: briggs sl. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2527-32. doi: 10.1016/s0960-894x(98)00447-8. Bioorg Med Chem Lett. 1998. PMID: 9873574

7

The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element.

Wiley MR, Weir LC, Briggs SL, Chirgadze NY, Clawson D, Gifford-Moore DS, Schacht AL, Smith GF, Vasudevan V, Zornes LL, Klimkowski VJ. Wiley MR, et al. Among authors: briggs sl. Bioorg Med Chem Lett. 1999 Sep 20;9(18):2767-72. doi: 10.1016/s0960-894x(99)00459-x. Bioorg Med Chem Lett. 1999. PMID: 10509932

8

The crystal structure of human alpha-thrombin complexed with LY178550, a nonpeptidyl, active site-directed inhibitor.

Chirgadze NY, Sall DJ, Klimkowski VJ, Clawson DK, Briggs SL, Hermann R, Smith GF, Gifford-Moore DS, Wery JP. Chirgadze NY, et al. Among authors: briggs sl. Protein Sci. 1997 Jul;6(7):1412-7. doi: 10.1002/pro.5560060705. Protein Sci. 1997. PMID: 9232642 Free PMC article.

9

Structure-based design of potent, amidine-derived inhibitors of factor Xa: evaluation of selectivity, anticoagulant activity, and antithrombotic activity.

Wiley MR, Weir LC, Briggs S, Bryan NA, Buben J, Campbell C, Chirgadze NY, Conrad RC, Craft TJ, Ficorilli JV, Franciskovich JB, Froelich LL, Gifford-Moore DS, Goodson T Jr, Herron DK, Klimkowski VJ, Kurz KD, Kyle JA, Masters JJ, Ratz AM, Milot G, Shuman RT, Smith T, Smith GF, Tebbe AL, Tinsley JM. Wiley MR, et al. J Med Chem. 2000 Mar 9;43(5):883-99. doi: 10.1021/jm9903287. J Med Chem. 2000. PMID: 10715155

10

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy.

Zhang M, Bailey DL, Bastian JA, Briggs SL, Chirgadze NY, Clawson DK, Denney ML, Gifford-Moore DS, Harper RW, Johnson LM, Klimkowski VJ, Kohn TJ, Lin HS, McCowan JR, Richett ME, Sall DJ, Smith AJ, Smith GF, Snyder DW, Takeuchi K, Utterback BG, Yan SC. Zhang M, et al. Among authors: briggs sl. Bioorg Med Chem Lett. 1999 Mar 8;9(5):775-80. doi: 10.1016/s0960-894x(99)00074-8. Bioorg Med Chem Lett. 1999. PMID: 10201846

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