Baxter AJ - Search Results

1

(R)-2-(3-mercapto-2(S)-methyl-1-oxo-propoxy)-3-(methylthio)propanoic acid, the first ultra-short-acting angiotensin converting enzyme inhibitor.

Baxter AJ, Carr RD, Eyley SC, Fraser-Rae L, Hallam C, Harper ST, Hurved PA, King SJ, Meghani P. Baxter AJ, et al. J Med Chem. 1992 Oct 2;35(20):3718-20. doi: 10.1021/jm00098a019. J Med Chem. 1992. PMID: 1433185 No abstract available.

2

Discovery of small molecule human C5a receptor antagonists.

Sanganee HJ, Baxter A, Barber S, Brown AJ, Grice D, Hunt F, King S, Laughton D, Pairaudeau G, Thong B, Weaver R, Unitt J. Sanganee HJ, et al. Among authors: baxter a. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1143-7. doi: 10.1016/j.bmcl.2008.12.104. Epub 2008 Dec 31. Bioorg Med Chem Lett. 2009. PMID: 19171482

3

Non-covalent inhibitors of rhinovirus 3C protease.

Baxter A, Chambers M, Edfeldt F, Edman K, Freeman A, Johansson C, King S, Morley A, Petersen J, Rawlins P, Spadola L, Thong B, Van de Poël H, Williams N. Baxter A, et al. Bioorg Med Chem Lett. 2011 Jan 15;21(2):777-80. doi: 10.1016/j.bmcl.2010.11.110. Epub 2010 Nov 26. Bioorg Med Chem Lett. 2011. PMID: 21183345

4

Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator.

Baxter AJ, Dixon J, Ince F, Manners CN, Teague SJ. Baxter AJ, et al. J Med Chem. 1993 Sep 17;36(19):2739-44. doi: 10.1021/jm00071a004. J Med Chem. 1993. PMID: 7692047

5

Discovery of small molecule human FPR1 receptor antagonists.

Unitt J, Fagura M, Phillips T, King S, Perry M, Morley A, MacDonald C, Weaver R, Christie J, Barber S, Mohammed R, Paul M, Cook A, Baxter A. Unitt J, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):2991-7. doi: 10.1016/j.bmcl.2011.03.049. Epub 2011 Mar 21. Bioorg Med Chem Lett. 2011. PMID: 21486695

6

Novel P2X7 receptor antagonists.

Alcaraz L, Baxter A, Bent J, Bowers K, Braddock M, Cladingboel D, Donald D, Fagura M, Furber M, Laurent C, Lawson M, Mortimore M, McCormick M, Roberts N, Robertson M. Alcaraz L, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4043-6. doi: 10.1016/j.bmcl.2003.08.033. Bioorg Med Chem Lett. 2003. PMID: 14592504

7

Peptidomimetic aminomethylene ketone inhibitors of interleukin-1 beta-converting enzyme (ICE).

Semple G, Ashworth DM, Batt AR, Baxter AJ, Benzies DW, Elliot LH, Evans DM, Franklin RJ, Hudson P, Jenkins PD, Pitt GR, Rooker DP, Yamamoto S, Isomura Y. Semple G, et al. Among authors: baxter aj. Bioorg Med Chem Lett. 1998 Apr 21;8(8):959-64. doi: 10.1016/s0960-894x(98)00136-x. Bioorg Med Chem Lett. 1998. PMID: 9871520

8

Thrombin inhibitors based on [5,5] trans-fused indane lactams.

Pass M, Abu-Rabie S, Baxter A, Conroy R, Coote SJ, Craven AP, Finch H, Hindley S, Kelly HA, Lowdon AW, McDonald E, Mitchell WL, Pegg NA, Procopiou PA, Ramsden NG, Thomas R, Walker DA, Watson NS, Jhoti H, Mooney CJ, Tang CM, Thomas PJ, Parry S, Patel C. Pass M, et al. Bioorg Med Chem Lett. 1999 Jun 21;9(12):1657-62. doi: 10.1016/s0960-894x(99)00244-9. Bioorg Med Chem Lett. 1999. PMID: 10397495

9

Potent human immunodeficiency virus type 1 protease inhibitors that utilize noncoded D-amino acids as P2/P3 ligands.

Jungheim LN, Shepherd TA, Baxter AJ, Burgess J, Hatch SD, Lubbehusen P, Wiskerchen M, Muesing MA. Jungheim LN, et al. Among authors: baxter aj. J Med Chem. 1996 Jan 5;39(1):96-108. doi: 10.1021/jm950576c. J Med Chem. 1996. PMID: 8568831

10

Hit-to-Lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists.

Baxter A, Bent J, Bowers K, Braddock M, Brough S, Fagura M, Lawson M, McInally T, Mortimore M, Robertson M, Weaver R, Webborn P. Baxter A, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4047-50. doi: 10.1016/j.bmcl.2003.08.034. Bioorg Med Chem Lett. 2003. PMID: 14592505

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