Newell DR - Search Results

1

In vivo and ex vivo magnetic resonance spectroscopy as applied to pharmacokinetic studies with anticancer agents: a review.

Newell DR, Maxwell RJ, Golding BT. Newell DR, et al. NMR Biomed. 1992 Sep-Oct;5(5):273-8. doi: 10.1002/nbm.1940050514. NMR Biomed. 1992. PMID: 1449968 Review.

2

19F nuclear magnetic resonance imaging of drug distribution in vivo: the disposition of an antifolate anticancer drug in mice.

Maxwell RJ, Frenkiel TA, Newell DR, Bauer C, Griffiths JR. Maxwell RJ, et al. Among authors: newell dr. Magn Reson Med. 1991 Jan;17(1):189-96. doi: 10.1002/mrm.1910170122. Magn Reson Med. 1991. PMID: 2067393

3

Pharmacokinetic studies with the antifolate C2-desamino-C2-methyl-N10-propargyl-2'-trifluoromethyl-5,8-dideazafolic acid (CB3988) in mice and rats using in vivo 19F-NMR spectroscopy.

Newell DR, Maxwell RJ, Bisset GM, Jodrell DI, Griffiths JR. Newell DR, et al. Br J Cancer. 1990 Nov;62(5):766-72. doi: 10.1038/bjc.1990.376. Br J Cancer. 1990. PMID: 2245168 Free PMC article.

4

Pharmacokinetic determinants of the activity and toxicity of antitumour agents.

Newell DR. Newell DR. Cancer Surv. 1989;8(3):557-603. Cancer Surv. 1989. PMID: 2701085 Review.

5

The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy.

Griffin RJ, Curtin NJ, Newell DR, Golding BT, Durkacz BW, Calvert AH. Griffin RJ, et al. Among authors: newell dr. Biochimie. 1995;77(6):408-22. doi: 10.1016/0300-9084(96)88154-5. Biochimie. 1995. PMID: 7578423 Review.

6

Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines).

Arris CE, Bleasdale C, Calvert AH, Curtin NJ, Dalby C, Golding BT, Griffin RJ, Lunn JM, Major GN, Newell DR. Arris CE, et al. Among authors: newell dr. Anticancer Drug Des. 1994 Oct;9(5):401-8. Anticancer Drug Des. 1994. PMID: 7945724 No abstract available.

7

Can pharmacokinetic and pharmacodynamic studies improve cancer chemotherapy?

Newell DR. Newell DR. Ann Oncol. 1994;5 Suppl 4:9-14; discussion 15. doi: 10.1093/annonc/5.suppl_4.s9. Ann Oncol. 1994. PMID: 8060901 Review.

8

Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors.

Rafi I, Boddy AV, Calvete JA, Taylor GA, Newell DR, Bailey NP, Lind MJ, Green M, Hines J, Johnstone A, Clendeninn N, Calvert AH. Rafi I, et al. Among authors: newell dr. J Clin Oncol. 1998 Mar;16(3):1131-41. doi: 10.1200/JCO.1998.16.3.1131. J Clin Oncol. 1998. PMID: 9508200 Clinical Trial.

9

Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

Griffin RJ, Srinivasan S, Bowman K, Calvert AH, Curtin NJ, Newell DR, Pemberton LC, Golding BT. Griffin RJ, et al. Among authors: newell dr. J Med Chem. 1998 Dec 17;41(26):5247-56. doi: 10.1021/jm980273t. J Med Chem. 1998. PMID: 9857092

10

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.

Curtin NJ, Bowman KJ, Turner RN, Huang B, Loughlin PJ, Calvert AH, Golding BT, Griffin RJ, Newell DR. Curtin NJ, et al. Among authors: newell dr. Br J Cancer. 1999 Aug;80(11):1738-46. doi: 10.1038/sj.bjc.6690591. Br J Cancer. 1999. PMID: 10468290 Free PMC article.

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