Lee K - Search Results

1

A novel macrocyclic tetrapeptide mimetic that exhibits low-picomolar Grb2 SH2 domain-binding affinity.

Shi ZD, Lee K, Liu H, Zhang M, Roberts LR, Worthy KM, Fivash MJ, Fisher RJ, Yang D, Burke TR Jr. Shi ZD, et al. Among authors: lee k. Biochem Biophys Res Commun. 2003 Oct 17;310(2):378-83. doi: 10.1016/j.bbrc.2003.09.029. Biochem Biophys Res Commun. 2003. PMID: 14521921

2

Design and synthesis of a beta-amino phosphotyrosyl mimetic suitably protected for peptide synthesis.

Lee K, Zhang M, Yang D, Burke TR Jr. Lee K, et al. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3399-401. doi: 10.1016/s0960-894x(02)00783-7. Bioorg Med Chem Lett. 2002. PMID: 12419370

3

Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems.

Wei CQ, Gao Y, Lee K, Guo R, Li B, Zhang M, Yang D, Burke TR Jr. Wei CQ, et al. Among authors: lee k. J Med Chem. 2003 Jan 16;46(2):244-54. doi: 10.1021/jm0203635. J Med Chem. 2003. PMID: 12519063

4

CD45 protein-tyrosine phosphatase inhibitor development.

Lee K, Burke TR Jr. Lee K, et al. Curr Top Med Chem. 2003;3(7):797-807. doi: 10.2174/1568026033452267. Curr Top Med Chem. 2003. PMID: 12678845 Review.

5

Utilization of a beta-aminophosphotyrosyl mimetic in the design and synthesis of macrocyclic Grb2 SH2 domain-binding peptides.

Lee K, Zhang M, Liu H, Yang D, Burke TR Jr. Lee K, et al. J Med Chem. 2003 Jun 19;46(13):2621-30. doi: 10.1021/jm030049q. J Med Chem. 2003. PMID: 12801226

6

Phosphotyrosyl mimetics in the development of signal transduction inhibitors.

Burke TR Jr, Lee K. Burke TR Jr, et al. Among authors: lee k. Acc Chem Res. 2003 Jun;36(6):426-33. doi: 10.1021/ar020127o. Acc Chem Res. 2003. PMID: 12809529 Review.

7

Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase.

Lee K, Gao Y, Yao ZJ, Phan J, Wu L, Liang J, Waugh DS, Zhang ZY, Burke TR Jr. Lee K, et al. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2577-81. doi: 10.1016/s0960-894x(03)00481-5. Bioorg Med Chem Lett. 2003. PMID: 12852970

8

Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.

Liu DG, Gao Y, Voigt JH, Lee K, Nicklaus MC, Wu L, Zhang ZY, Burke TR Jr. Liu DG, et al. Among authors: lee k. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3005-7. doi: 10.1016/s0960-894x(03)00635-8. Bioorg Med Chem Lett. 2003. PMID: 12941322

9

High-resolution structure of the Yersinia pestis protein tyrosine phosphatase YopH in complex with a phosphotyrosyl mimetic-containing hexapeptide.

Phan J, Lee K, Cherry S, Tropea JE, Burke TR Jr, Waugh DS. Phan J, et al. Among authors: lee k. Biochemistry. 2003 Nov 18;42(45):13113-21. doi: 10.1021/bi030156m. Biochemistry. 2003. PMID: 14609321

10

Synthesis of a 5-methylindolyl-containing macrocycle that displays ultrapotent Grb2 SH2 domain-binding affinity.

Shi ZD, Lee K, Wei CQ, Roberts LR, Worthy KM, Fisher RJ, Burke TR Jr. Shi ZD, et al. Among authors: lee k. J Med Chem. 2004 Feb 12;47(4):788-91. doi: 10.1021/jm030440b. J Med Chem. 2004. PMID: 14761181

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