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XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys.
Cundy KC, Annamalai T, Bu L, De Vera J, Estrela J, Luo W, Shirsat P, Torneros A, Yao F, Zou J, Barrett RW, Gallop MA. Cundy KC, et al. Among authors: gallop ma. J Pharmacol Exp Ther. 2004 Oct;311(1):324-33. doi: 10.1124/jpet.104.067959. Epub 2004 May 14. J Pharmacol Exp Ther. 2004. PMID: 15146029
XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters.
Cundy KC, Branch R, Chernov-Rogan T, Dias T, Estrada T, Hold K, Koller K, Liu X, Mann A, Panuwat M, Raillard SP, Upadhyay S, Wu QQ, Xiang JN, Yan H, Zerangue N, Zhou CX, Barrett RW, Gallop MA. Cundy KC, et al. Among authors: gallop ma. J Pharmacol Exp Ther. 2004 Oct;311(1):315-23. doi: 10.1124/jpet.104.067934. Epub 2004 May 14. J Pharmacol Exp Ther. 2004. PMID: 15146028
27 results