Smith GC - Search Results

1

Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.

Veuger SJ, Curtin NJ, Richardson CJ, Smith GC, Durkacz BW. Veuger SJ, et al. Among authors: smith gc. Cancer Res. 2003 Sep 15;63(18):6008-15. Cancer Res. 2003. PMID: 14522929

2

DNA-dependent protein kinase and related proteins.

Smith GC, Divecha N, Lakin ND, Jackson SP. Smith GC, et al. Biochem Soc Symp. 1999;64:91-104. Biochem Soc Symp. 1999. PMID: 10207623 Review.

3

Competitive and noncompetitive inhibition of the DNA-dependent protein kinase.

Izzard RA, Jackson SP, Smith GC. Izzard RA, et al. Among authors: smith gc. Cancer Res. 1999 Jun 1;59(11):2581-6. Cancer Res. 1999. PMID: 10363977

4

Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035).

Stockley M, Clegg W, Fontana G, Golding BT, Martin N, Rigoreau LJ, Smith GC, Griffin RJ. Stockley M, et al. Among authors: smith gc. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2837-41. doi: 10.1016/s0960-894x(01)00537-6. Bioorg Med Chem Lett. 2001. PMID: 11597411

5

A FlashPlate assay for the identification of PARP-1 inhibitors.

Dillon KJ, Smith GC, Martin NM. Dillon KJ, et al. Among authors: smith gc. J Biomol Screen. 2003 Jun;8(3):347-52. doi: 10.1177/1087057103008003013. J Biomol Screen. 2003. PMID: 12857389

6

2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).

Hollick JJ, Golding BT, Hardcastle IR, Martin N, Richardson C, Rigoreau LJ, Smith GC, Griffin RJ. Hollick JJ, et al. Among authors: smith gc. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3083-6. doi: 10.1016/s0960-894x(03)00652-8. Bioorg Med Chem Lett. 2003. PMID: 12941339

7

Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.

Veuger SJ, Curtin NJ, Smith GC, Durkacz BW. Veuger SJ, et al. Among authors: smith gc. Oncogene. 2004 Sep 23;23(44):7322-9. doi: 10.1038/sj.onc.1207984. Oncogene. 2004. PMID: 15286704

8

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.

Leahy JJ, Golding BT, Griffin RJ, Hardcastle IR, Richardson C, Rigoreau L, Smith GC. Leahy JJ, et al. Among authors: smith gc. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7. doi: 10.1016/j.bmcl.2004.09.060. Bioorg Med Chem Lett. 2004. PMID: 15546735

9

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.

Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, Smith GC. Hickson I, et al. Among authors: smith gc. Cancer Res. 2004 Dec 15;64(24):9152-9. doi: 10.1158/0008-5472.CAN-04-2727. Cancer Res. 2004. PMID: 15604286

10

Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

Griffin RJ, Fontana G, Golding BT, Guiard S, Hardcastle IR, Leahy JJ, Martin N, Richardson C, Rigoreau L, Stockley M, Smith GC. Griffin RJ, et al. Among authors: smith gc. J Med Chem. 2005 Jan 27;48(2):569-85. doi: 10.1021/jm049526a. J Med Chem. 2005. PMID: 15658870

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