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Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus.
Zhang N, Chen HM, Koch V, Schmitz H, Liao CL, Bretner M, Bhadti VS, Fattom AI, Naso RB, Hosmane RS, Borowski P. Zhang N, et al. Among authors: borowski p. J Med Chem. 2003 Sep 11;46(19):4149-64. doi: 10.1021/jm030842j. J Med Chem. 2003. PMID: 12954067
A novel imidazole nucleoside containing a diaminodihydro-S-triazine as a substituent: inhibitory activity against the West Nile virus NTPase/helicase.
Ujjinamatada RK, Agasimundin YS, Zhang P, Hosmane RS, Schuessler R, Borowski P, Kalicharran K, Fattom A. Ujjinamatada RK, et al. Among authors: borowski p. Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1775-88. doi: 10.1080/15257770500267063. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16438047
An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-beta-D-ribofuranoside.
Ujjinamatada RK, Baier A, Borowski P, Hosmane RS. Ujjinamatada RK, et al. Among authors: borowski p. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2285-8. doi: 10.1016/j.bmcl.2007.01.074. Epub 2007 Jan 27. Bioorg Med Chem Lett. 2007. PMID: 17289387 Free PMC article.
Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme.
Borowski P, Lang M, Haag A, Schmitz H, Choe J, Chen HM, Hosmane RS. Borowski P, et al. Antimicrob Agents Chemother. 2002 May;46(5):1231-9. doi: 10.1128/AAC.46.5.1231-1239.2002. Antimicrob Agents Chemother. 2002. PMID: 11959550 Free PMC article.
Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses.
Bretner M, Schalinski S, Haag A, Lang M, Schmitz H, Baier A, Behrens SE, Kulikowski T, Borowski P. Bretner M, et al. Among authors: borowski p. Antivir Chem Chemother. 2004 Jan;15(1):35-42. doi: 10.1177/095632020401500104. Antivir Chem Chemother. 2004. PMID: 15074713 Free article.
68 results